Background: Mentha longifolia is one of the aromatic medicinal plant belongs to Lamiaceae family. There are some active ingredients in the essential oil of M. longifolia, which potentially could impair the hepatic function. The aim of this study was to find the maximum dose of essential oil of M. longifolia (EOML) that does not show any hepatic deterioration. Methods: Adult Wistar rats fed d...

The hepatotoxic action of allyl formate on rat liver has been investigated. Biochemical changes can be detected in the liver cell many hours before the histological changes and it would appear that the toxin has a direct action on the liver parenchymal cell. The results suggest that allyl formate is not the toxic agent but that it is converted via allyl alcohol into acrolein. This reaction requ...

To establish a predictive in vitro cardiovascular toxicity and hepatotoxicity screening system, whole cells from the neonatal rat heart and rat hepatocytes were cultured with known cardiotoxic and hepatotoxic compounds and cytotoxicities were assessed. The heart cells were isolated from neonatal SD rats by enzyme digestion and cultured on type I collagen gel. After a several days of preculture,...

Water blooms formed by potentially toxic species of cyanobacteria are a common phenomenon in the Baltic Sea in late summer. Twenty-five cyanobacterial bloom samples were collected from open and coastal waters of the Baltic Sea during 1985 to 1987, and their toxicity was determined by mouse bioassay. All of 5 bloom samples from the southern Baltic Sea, 6 of 6 from the open northern Baltic Sea (G...

Precision-cut liver slices (PCLS) preserve the tissular organization of the organ and represent an in vitro model closer to in vivo conditions than hepatocytes cultures. As this may be an interesting tool not only for the investigation of hepatotoxic and protective effects but also for bioguided fractionations schemes, the usefulness of PCLS was compared with an in vivo test of liver function. ...

Isoniazid, pyrazinamide and rifampicin have hepatotoxic potential, and can lead to such reactions during antituberculosis chemotherapy. Most of the hepatotoxic reactions are dose-related; some are, however, caused by drug hypersensitivity. The immunogenetics of antituberculosis drug-induced hepatotoxicity, especially inclusive of acetylaor phenotype polymorphism, have been increasingly unravell...

Introduction: In many cultures fasting is recommended as a way to protect and promote health. However, there are few studies on the effects of fasting on organ function and resistance to toxic agents such as drugs. This study was conducted to investigate the effect of short-term periodic fasting on the acetaminophen hepatotoxic effects in mice. Methods: In this...