Glycated hemoglobin A1c (HbA1c) is routinely used in the diagnosis of diabetes mellitus (DM) and for monitoring the long-term glycemic control in patients already diagnosed with DM. HbA1c is measured in the clinical laboratory based either on the charge of the glycated molecule by cation exchange high performance liquid chromatography (CE-HPLC) or electrophoresis, or on the physical structure o...

OBJECTIVE To assess the relative importance of fasting and postprandial hyperglycemia to vascular dysfunction in diabetes, we have measured indicators of glycation, oxidative and nitrosative stress in subjects with type 1 diabetes, and different postprandial glucose patterns. RESEARCH DESIGN AND METHODS Plasma and urinary levels of specific arginine- and lysine-derived advanced glycation end ...

Severe hypoglycemia occurs in intensively treated patients with type 1 diabetes mellitus (T1DM) due in part to deficient epinephrine counterregulatory responses. Previously, we have found that T1DM patients demonstrated a spectrum of altered responses to epinephrine at a variety of target organs compared with nondiabetic healthy subjects. What is not known is whether intensive glycemic control ...

INTRODUCTION Glycated hemoglobin (HbA1c) can be altered in different conditions. We hypothesize that HbA1c levels may change due to altered thyroid status, possibly due to changes in red blood cell (RBC) turnover. OBJECTIVES The objective of this study was to determine the effects of altered thyroid status on HbA1c levels in individuals without diabetes, with overt hyper- and hypo-thyroidism,...

background: anemia may be considered to be an independent risk factor for the development of diabetic retinopathy (dr) in patients with renal failure. the purpose of this study was to investigate the association between blood hemoglobin level and retinopathy in diabetic patients with normal renal function tests.methods: from 2009 to 2011, 1100 diabetic patients underwent retinal examination. am...

BACKGROUND Diabetes is a major public health concern. In spite of continuous new drug development to treat diabetes, herbal remedies remain a potential adjunct therapy to maintain better glycemic control while also imparting few side-effects. Portulaca oleracea has been traditionally used to manage several diseases due to the anti-oxidant and anti-atherogenic effects it imparts. To better under...

Potential of Family Health Strategy Against Cardiovascular Disease Gilberto Andrade Tavares1 and José Augusto Soares Barreto-Filho2,3,4 Núcleo de Pós-Graduação em Ciências da Saúde da Universidade Federal de Sergipe (UFS),1 São Cristóvão, SE; Núcleo de Pós-Graduação em Medicina Universidade Federal de Sergipe;2 Divisão de Cardiologia Hospital Universitário;3 Clínica e Hospital São Lucas,4 Araca...