CONTEXT We studied two families from Galicia (northwest Spain) with Pendred syndrome (PS) and unusual thyroid phenotypes. In family A, the proposita had a large goiter and hypothyroxinemia but normal TSH and free T3 (FT3). In family B, some affected members showed deafness but not goiter. OBJECTIVE Our objective was to identify the mutations causing PS and molecular mechanisms underlying the ...

Abstract. It is well known that iodine is an indispensable component of thyroid hormones. The discovery of iodine deficiency and its adverse effects upon human beings is an instructive example of the transfer of scientific and medical knowledge to the benefit of the public health. Physicians have known for more than a century that deficient iodine intake is associated with endemic goiter, creti...

The usefulness of selective embolization thyroid arteries in the treatment voluminous goiters is reported on a 55-year-old patient with grade 3 goiter. Selective arteriography was used to embolize arteries. Radiological reduced volume goiter significantly, resolving compressive symptoms, improving dysphonia and respiratory mechanics, maintaining normal function. before resection can successfull...

A girl who had a nontoxic diffuse goiter with a congenital organification defect of iodide was first seen at the age of 8 years, and since then she has been followed up for a long period. The nodularity of the thyroid gland had gradually progressed, because of intermittent failure of ingestion of thyroid hormone preparation which was followed by excess TSH secretion. 18 years later, a nodular g...

Even the thyroid, like all the other organs and tissues, has undergone anatomic-functional modifications during the senescence. One of the characteristics of ageing is the significant increase of thyroid disease and their different clinical expression. Moreover, thyroid disease in older patients requires special attention because of the increased gravity caused by the frequent co-existence of o...

Background: The kidney has an important role in the metabolism of thyroid hormones. Impaired renal function and the resulting accumulation of uremic toxins may disturb thyroid physiology at various levels. The prevalence of goiter and thyroid nodules is significantly increased in patients with ESRD compared with other hospitalized patients admitted for treatment of non-renal disease. The purpos...

BACKGROUND Many authors have claimed that hyperthyroidism protects against thyroid cancer and believed that the incidence of malignancy is lower in patients with toxic multinodular goiter (TMG) than in those with non-toxic multinodular goiter. But in recent studies, it was reported that the incidence of malignancy with TMG is not as low as previously thought. AIM To compare the thyroid cancer...

objective in this study, we investigated the changes of the serum levels of thyroidhormones including thyroxine (t4), triiodothyronine (t3), t3 resin uptake andthyroid stimulating hormone (tsh) in epileptic children during treatment withanti-epileptic drugs (aeds) including carbamazepine (cbz), primidone (prm),phenobarbital and valproic acid (vpa). materials and methods this study consisted of ...

We examined 812 subjects with a history of radiation to the head for the treatment of scalp worm infestation in during childhood. 36% of the subjects had goiters grades IA and II3. Another 134 subjects ( 17%) were found to have thyroid nodularity, 85 of whom bad solitary cold nodules. 43 patients whith either a solitary cold nodule or a multinodular goiter with a priominent cold nodule were ope...