Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin lymphoma. DLBCL is a molecularly heterogeneous disease, and the addition of Rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) has significantly improved the survival of patients. Gene expression profiling studies revealed that DLBCL comprises two main subgroup...

The light emitting diode (LED) is widely used in modern solid-state lighting applications, and its output efficiency is closely related to the submounts' material properties. Most submounts used today, such as low-power printed circuit boards (PCBs) or high-power metal core printed circuit boards (MCPCBs), are not transparent and seriously decrease the output light extraction. To meet the requi...

Undifferentiated nasopharyngeal carcinoma (NPC) is 100% associated with Epstein-Barr virus (EBV). Expression of viral proteins in the tumor cells is highly restricted. EBV reactivation by CytoLytic Virus Activation (CLVA) therapy triggers de novo expression of early viral kinases (PK and TK) and uses antiviral treatment to kill activated cells. The mechanism of tumor elimination by CLVA was ana...

Background SLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) undergo somatic hypermutations and class-switch recombination, which can cause genotoxic stress. Hence, we tested whether expression needs be suppressed in G...

BACKGROUND We studied the clinicopathological characteristics and prognoses of localized stage thyroid diffuse large B-cell lymphoma (DLBCL). PATIENTS AND METHODS This study included 32 patients with stage I/IIE thyroid DLBCL. Their median age was 66 years, the male/female ratio was 10/22. RESULTS As to the cellular immunophenotype, CD20 was positive in 31/32, CD5 in 0/32, CD10 in 4/32, CD2...

Gene-expression profiling has identified 3 major subgroups of diffuse large B-cell lymphoma (DLBCL): germinal center B-cell-like (GCB), activated B-cell-like (ABC), and primary mediastinal DLBCL (PMBCL). Using comparative genomic hybridization (CGH), we investigated the genetic alterations of 224 cases of untreated DLBCL (87 GCB-DLBCL, 77 ABC-DLBCL, 19 PMBCL, and 41 unclassified DLBCL) previous...

In online learning, a player chooses actions to play and receives reward and feedback from the environment with the goal of maximizing her reward over time. In this paper, we propose the model of combinatorial partial monitoring games with linear feedback, a model which simultaneously addresses limited feedback, infinite outcome space of the environment and exponentially large action space of t...

We utilized gene expression profiling of a comprehensive panel of purified developmentally defined normal murine B cells to identify unique transcriptional signatures for each subset. To elucidate transcription factor activities that function in a stage-specific fashion, we used gene sets that share transcription factor targets and found that germinal center B cells had a robust enrichment of u...

Green consumption is an important tool to accelerate the circular economy and promote sustainable development. The identification of critical influencing factors for green key promoting behavior (GCB). Firstly, based on joint framework theory planned (TPB) attitude–behavior–context (ABC) theory, we summarized 32 from six dimensions: consumer attitude, cognitive factors, sense responsibility, ec...

This paper proposes a resonant dc link in PWM ac chopper. This can solve the spike problems and also reduce the switching loss. The configuration and PWM pattern of the proposed technique are presented. The simulation results are used to confirm the theory. Keywords—PWM ac chopper and Resonant dc link.