The development of imatinib has revolutionized the treatment of chronic myeloid leukemia. Follow-up analysis of IRIS trial participants continues to demonstrate durable responses for imatinib at 400 mg/day. However, 10%-15% of patients with chronic myeloid leukemia will become imatinib-resistant or intolerant of adverse events. Phase II studies have shown that most of these patients will respon...

Mantle cell lymphoma is one of the most challenging hematologic malignancies, owing to an aggressive disease course, a high rate of relapse, and lack of standard of care. In the United States, mantle cell lymphoma accounts for approximately 6% of all newly diagnosed cases of non-Hodgkin lymphoma. Because most patients are initially diagnosed with advanced-stage disease, they are often symptomat...

Th is study investigates the eff ects of challenge and hindrance stressors and exhaustion on frontline hotel employees’ turnover intentions and whether hope, as a personal resource, can moderate the deleterious eff ects of these antecedents on turnover intentions. Data were collected from a sample of 183 full-time frontline employees working in 5-star and 4-star hotels in Northern Cyprus. To en...

Purposes: To investigate the policy-making process of introducing a prospective payment method called ‘Payment by Results in mental health’in England and to identify the factors that caused the delay in implementation. This study carried out a three-stage analysis using mixed-methods. Firstly, the feasibility of applying Quasi-market theory in mental health care at the fundamental level was the...

Successfully transitioning to person-centered care in nursing homes requires a new approach to solving care issues. The adaptive leadership framework suggests that expert providers must support frontline caregivers in their efforts to develop high-quality, person-centered solutions.

AS WE STARTED our Magnet® journey over 7 years ago, shared governance had a genuine appeal. The nurses at our organization were excited about having a voice in their workplace to impact patient care, patient safety, practice issues, and research. We wanted to set the world on fire with the latest and greatest shared governance ever seen within a Magnet organization! This article describes how w...

Bacterial pathogens must suppress host defences to cause disease. New research shows that the Pseudomonas effector protein AvrPto does so by directly targeting plant transmembrane receptor kinases involved in bacterial perception.

A recent study designed to investigate a possible psychological mechanism behind the widespread indifference or opposition towards immortalism is presented. In the wider context of a psychological experiment, which is not reported in detail here, the study tested different ways to advertise immortalism, but failed to identify a superior strategy. The theory behind the study, possible explanatio...

Sparked by high-profile confrontations between police and citizens in Ferguson, Missouri, and elsewhere, many commentators have criticized the excessive militarization of law enforcement. We investigate whether surplus military-grade equipment acquired by local police departments from the Pentagon has an effect on crime rates. We use temporal variations in US military expenditure and betweencou...