OBJECTIVE We tested the hypothesis that brain pathology is associated with the rate of progression of physical frailty in older adults. METHODS A total of 791 older adults participating in the Religious Orders Study and Memory and Aging Project had annual clinical evaluations from which a previously established composite measure of physical frailty was derived and brain autopsy after death. A...

background: the study was developed in order to find a subset of potential factors, which affect birth distance pattern, regarding consideration on correlation of events of birth in a family and correlation within clusters/centers which other studies omit these correlations. methods: referring to documents that were registered for family in the health care centers on socio-economical zone, we c...

BACKGROUND Time to first pregnancy (TTFP) has never been studied in an Iranian setting. Lifestyle, occupational and environmental factors have been suggested to affect the female reproduction. OBJECTIVE This study was conducted to measure TTFP in the south of Iran and survey the effects of several similar factors on TTFP by frailty models. MATERIALS AND METHODS The data on TTFP were availab...

BACKGROUND Uncomplicated frailty instruments are desirable for use in a busy clinical setting. The aim of this study was to operationalize a frailty index (FI) from routine blood and urine tests, and to evaluate the properties of this FI compared to other frailty instruments. MATERIALS AND METHODS We conducted a secondary analysis of a prospective cohort study on 306 patients aged ≥65 years h...

Background: Several scoring systems are available to evaluate the cardiac surgery risk. Frailty increases the risk of adverse outcomes after surgery. The Frailty evaluation system is a relatively new method, and in this study, we compared the frailty scoring method with the conventional Euroscore method. Methods: This cross-sectional study was performed on 88 elderly patients (over 65 years of...

Survival Model is widely used in medical field and biostatistics. This model can be used to identify the risk factors of an event and can handle the situation when risk factors change with time. Timing of an event frequently depends on the location (spatial) called as spatial survival model. In the development, survival modeling also included random effects models (frailty) to overcome the hete...