The inhibitory effect of human alpha-fetoprotein on the protein synthesis (incorporation of [3H]leucine into the total protein fraction) weas observed in a rabbit reticulocyte lysate cell-free system. The incorporation was inhibited to 50% of the control level by 14-16 microM alpha-fetoprotein, and decreased to about 15% at a concentration higher than 40 microM. An almost identical dose depende...

BACKGROUND/AIMS The aim of this study was to evaluate the feasibility of α-fetoprotein (AFP) as a diagnostic tool for hepatocellular carcinoma (HCC) in Korean patients. METHODS We retrospectively reviewed the medical records of HCC and cirrhosis patients at three hospitals. For each HCC patient, a cirrhosis patient matched for age, sex, etiology, and Child-Pugh classification was selected by ...

Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Although most HCCs seem to originate from the accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear. Long-term survival of HCC patients is also poor, partly due to HCC recurrence. Although serum alpha-fetoprotein (AFP) level i...

A prospective clinical evaluation is reported for analysis of maternal serum alpha fetoprotein (s.AFP) testing by recently developed enzymeimmunoassay automated systems. The reference method for the study was a manual competitive binding radioimmunoassay which has been utilized by us in the Maternal Serum AFP Screening Program at the Medical University of South Carolina for the past five years....

An uncommon case of undifferentiated carcinoma of the gall bladder in a 65 year old Chinese man, who presented with an increased serum alpha-fetoprotein concentration, is reported. Histologically, the tumour had a primitive appearance and was composed of a pavement-like array of poorly differentiated columnar/polygonal cells. Alpha-fetoprotein was demonstrated in some of the tumour cells using ...

Six-, 12and 20-week-old rats were fed N-nitrosomorpholine (NNM) at low concentrations (6 mg/kg/day) or high concentrations (20 mg/kg/day) for 6 or 12 weeks. Irrespective of the age of the rats, both NNM schedules resulted in development of hepatomas and during the early stages of hepatoma induction, liver histotoxic patterns depended only on the dose of carcinogen employed. Necrosis of hepatocy...

13 children with ataxia-telangiectasia were followed for 6 years. Unlike previously reported cases, these patients had progressive, debilitating neurological disease and slight pulmonary or infectious symptoms. Immunological dysfunction was variable and endocrinological defects were absent. Oculomotor findings, alpha-fetoprotein levels, and the incidence of chromosomal breakage were the most co...

Carcinoembryonic antigen (CEA), orosomucoid beta2 microglobulin, and alpha fetoprotein were quantified in the pleural fluid and serum of 58 hospitalized consecutive patients in order to differentiate malignant from nonmalignant effusions. Cytologic examination of the effusions was also performed. The orosomucoid assay was the most helpful in identifying malignant effusions; higher values (>100 ...

a-l-Fetoprotein (AFP) was measured in the sera of 5 hepatoma patients following total hepatectomy and orthotopic liver transplantation. Immunosuppressive therapy, rejection episodes, and infection did not alter the serum level of AFP. Low AFP levels persisting posttransplantation indicated the presence of slow-growing residual tumor in 3 patients. A sharp increase in serum AFP levels preceded c...

Serum fetuin-A levels are reportedly elevated in hyperthyroidism. However, there are few relevant epidemiologic studies. We conducted a cross-sectional study in Songnan community, China in 2009 to investigate the association between serum fetuin-A concentrations and thyroid function. A total of 2,984 participants aged 40 years and older were analyzed. Multivariable linear regression analysis re...