Background: Acute pain is common after arthroscopic surgeries and it is one of the most important causes of patient dissatisfaction, admission time and increased morbidity . Gabapentin with anti-hyperalgesic effects can play a critical role in pre-emptive analgesia methods. The aim of this study was to assess the efficacy of gabapentin in pain management after surgery and the rate of drug consu...

BACKGROUND This prospective, randomized, double-blind study was designed to evaluate the preemptive and preventive analgesic efficacy of adding magnesium to a multimodal regimen of patient-controlled epidural analgesia (PCEA) in patients undergoing abdominal hysterectomy. METHODS Ninety patients were randomly assigned to one of the three groups. Pre-magnesium patients received bolus of magnes...

BACKGROUND Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of clinical trials indicate that gabapentin and pregabalin could be effective as p...

This paper introduces schedulability analysis for global fixed priority scheduling with deferred pre-emption (gFPDS) for homogeneous multiprocessor systems. gFPDS is a superset of global fixed priority pre-emptive scheduling (gFPPS) and global fixed priority non-pre-emptive scheduling (gFPNS). We show how schedulability can be improved via appropriate choice of priority assignment and final non...

BACKGROUND The hepatic outcome of hepatitis B surface antigen (HBsAg) positive patients undergoing chemotherapy after withdrawal of pre-emptive lamivudine is unknown. AIMS To examine the occurrence of hepatitis B virus (HBV) reactivation after withdrawal of pre-emptive lamivudine. METHODS Pre-emptive lamivudine was started one week before initiation of chemotherapy in 46 consecutive HBsAg p...

OBJECTIVE To assess the efficacy of wound infiltration with local anesthetic in reducing postoperative pain after a muscle-splitting incision for appendectomy. DESIGN A double-blind, placebo-controlled, randomized clinical trial. SETTING The Royal Columbian Hospital, a university-affiliated community hospital. PARTICIPANTS Forty-three patients scheduled to undergo emergency appendectomy w...

Injection of formalin into the hindpaw of a rat induces a biphasic response in pain-related behaviours, such that C-fibre activation during phase 1 triggers a state of central sensitization characterized by a longer lasting phase 2. As the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) may participate in processing of nociceptive inputs, we hypothesized that pentobarbitone and propo...

In the linked study by Coura and collaborators , it is reported that acupuncture the day before surgery can reduce postoperative pain (see article on page 16). 1 Although the study is small and there are gender differences between the groups, the fi ndings are novel, suggesting that acupuncture may be used the day before surgery rather than given in the immediate preoperative period. This sugge...

Introduction Septorhinoplasty operates on cartilage and bone of the nose is ensued by severe postoperative pain. The objective this study to evaluate effects preoperative administration intravenous (IV) paracetamol ibuprofen pain scores in patients undergoing septorhinoplasty. Methodology 150 septorhinoplasty were randomly assigned into three groups with 50 each group. control group (Group A) w...