phenyl phenanthridinium bromide) has been shown to inhibit completely the incorporation of preformed purines into the nucleic acids of Ehrlich ascites carcinoma cells, but the drug does not ap preciably inhibit the incorporation of radioactive glycine into nucleic acids or proteins (4). These studies have been interpreted in terms of disrup tion of the normal relationship between intracellu lar...

The cytotoxic effects of bleomycin on HeLa cells in culture were enhanced by incubation of the cells with benzamide, a potent inhibitor of poly(ADP-ribose) polymerase, at concentrations at which benzamide alone did not show any cytotoxicity. Benzamide plus bleomycin display enhanced therapeutic effects against Ehrlich ascites tumor cells in vivo. On daily treatment with various doses of bleomyc...

The polymerization of N-carboxyglycine anhydride has been used to identify potential inhibitors of protein synthesis and hence of cancers. Polymerization inhibition was observed wi th N-me thylbis(2.chloroethyl)amine HC1, busulfan, I ,9-dimethylsulfonyloxynonane, phenyl isocyanate, etc. (14), tris(2-chloroethyl)amine HC1 (7), and chiorambudil (G. E. Moos and J. B. Morrison, unpublished data). I...

A method is described for the assay of thymidylate synthetase activity in crude ex tracts of Ehrlich ascites tumor. The method involves the use of tritiated deoxyuridine5'-phosphate as substrate. The inhibition of thymidylate synthetase by 5-fluorodeoxyuridine-5'-phosphate was measured in extracts from one 5-fluorouracil-sensitive and four drug-resistant lines of Ehrlich ascites tumor. A high d...

A method is described for the assay of thymidylate synthetase activity in crude ex tracts of Ehrlich ascites tumor. The method involves the use of tritiated deoxyuridine5'-phosphate as substrate. The inhibition of thymidylate synthetase by 5-fluorodeoxyuridine-5'-phosphate was measured in extracts from one 5-fluorouracil-sensitive and four drug-resistant lines of Ehrlich ascites tumor. A high d...

A novel binary compounds as 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-phenyl-2H-benzo[f]indazole-4,9-dione (10) and fused 2-hydroxy-3-(4-hydroxy-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)naphthalene-1,4-dione (7) naphtho[2,3-b]furan-3,4,9(2H)-trione (6) based on lawsone ‘that plays important precursor’ was synthesized by reaction with 1,3-diphenyl-1H-pyrazole-4-carbaldehyde halo-compounds, such 2-chlor...

The present study aimed to synthesize new metal complexes of diacetylmonoxime-N(4)antipyrinylthiosemicarbazone ligand and evaluate their antitumor activity. New with ferric, cobalt, nickel copper ions were prepared. Elemental, 1H Nuclear magnetic resonance, Mass spectroscopy, Electron paramagnetic Fourier Transform Infrared Spectroscopy, Ultraviolet–visible thermal gravimetric analysis used cha...

the methanolic extracts of indigofera aspalathoides (meia) and wedelia calendulaceae (mewc) were evaluated for their anticancer activity against ehrlich ascites carcinoma (eac) in swiss albino mice. on day 1, the extract of indigofera aspalathoides at a dose of 250 and 500 mg/kg body weight and the extract of wedelia calendulaceae at a dose of 250 and 500 mg/kg body weight were administered ora...