We describe the efficient synthesis of DTPA-conjugated oligosaccharides composed of alpha- and/or beta-linked tri to monoglucosamines. Gd(iii) complex with DTPA-conjugated chitotriitol has been reported to be an effective MRI contrast agent. In order to elucidate the structure-property relationships, we planned to synthesize the DTPA-conjugated 2-amino-tri-, di-, and monosaccharides varying in ...

Progress in the development of stem cell and gene therapy requires repeatable and non‑invasive techniques to monitor the survival and integration of stem cells in vivo with a high temporal and spatial resolution. The purpose of the present study was to examine the feasibility of using the standard contrast agent gadolinium diethylenetriamine pentaacetic acid (Gd‑DTPA) to label rat mesenchymal s...

PURPOSE Sustained-release intravitreal drug implants for posterior segment diseases are associated with significant complications. As an alternative, subconjunctival infusions of drug to the episclera of the back of the eye have been performed, but results in clinical trials for macular diseases showed mixed RESULTS To improve understanding of transscleral drug delivery to the posterior segme...

OBJECTIVE The mechanisms of dyspnea and exercise intolerance have not been fully elucidated. We aimed to investigate the clearance rate of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) from lungs in hyperthyroid patients without clinical evidence of lung disease and to explore the interactions between their Tc-99m DTPA radioaerosol lung scintigraphy, spirometric measurements, and ...

Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on the integrity of the hepatocyte mass, this uptake can be quantified to assess liver function. We report the relationship between the extent of Gd-EOB-DTPA uptake and the degree of liver fibrosis. T1-weighted volume-interpolate...

results indicate that after the injection of MSH(4-10)DTPA-l “In, radioactivity is eliminated from the blood with a physiological half-life of 0.19 h. This compares with 1 1 h for bisMSH-DTPA injected by the same route IS]. As a consequence of this rapid elimination, tumour radioactivity was well differentiated from the background by 4 h and at this time, the mean tumour/blood ratio was 10.6 f ...

Integrated Department of Immunology, National Jewish Medical and Research Center, Goodman Building, K510, 1400 Jackson Street, Denver, Colorado 80206, USA Department of Microbial and Molecular Pathogenesis, Texas A&M University System Health Science Center, College of Medicine, 407 Reynolds Medical Building, College Station, Texas 77843-1114, USA Corresponding author. Tel: +1 303 398 1767; Fax:...

Following is the comprehensive index for Volume 36 of the Hastings Center Report covering all feature material from 2006. Letters have not been included. Complete issues are available for Volume 36 (2006) and may be purchased for $16.00 each, plus shipping. Please contact the Circulation Department, The Hastings Center, 21 Malcolm Gordon Road, Garrison, NY 10524; tel.: (845) 424-4040; fax: (845...

Primary hepatic angiosarcoma is the most common malignant mesenchymal tumor of the liver. It has a poor prognosis and various appearances on magnetic resonance (MR) images. We report a case of hepatic angiosarcoma with a characteristic appearance on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging in the hepatobiliary phase. A 72-year-old man was adm...