Levetiracetam is a relatively new antiepileptic drug that has previously not been associated with severe dermatological side effects. We report the case of a 31-year-old male treated with levetiracetam for seizures who subsequently developed a mycosis fungoides-like drug reaction that resolved upon dosage reduction.

In many clinical trials, longitudinal or repeated measures data is collected in order to monitor the patient’s progress over time towards a clinical end-point. One method of accounting for the two outcomes is by using joint modelling methods. However, little work has been done on sample size calculations for studies which use joint modelling of longitudinal and time-to-event data to establish t...

In the past, survey researchers assumed that the respondents held opinions which could be obtained by asking the proper questions. This idea the “file drawing model” for survey response was criticized strongly by Converse in 1964, but also strongly defended by Achen (1975), Erikson (1978, 1979), and Judd et al. (1981). Zaller (1992) introduced the idea that people create their response on the s...

Remember the scene in the original Jurassic Park, when all the Land Rovers sputtered and stalled during the park tour? The rain was drumming hard on the roofs of the vehicles and tension began to rise. Slowly, the camera zoomed onto the surface of a still glass of water, and the surface began to ripple. Here, Spielberg was trying to give the sense of something big about to happen. Because he wa...

Background: Drug nano-carriers are one of the most important tools for targeted cancer therapy so that undesired side effects of chemotherapy drugs are minimized. In this area, the use of ultrasound can be helpful in controlling drug release from nanoparticles to achieve higher treatment efficiency.Objective: Here, we studies the effects of ultrasound irradiation on the release profile of 5-flu...

Background: Substance abuse disorders are associated with many serious medical and psychiatric problems. Undesirable side effects following drug-assisted treatment occur in drug abusers while sudden discontinuation of drug use can also cause unpleasant symptoms. This study hence investigated the effects of reality therapy (RT) on drug cravings and mental health among clients of therapeutic comm...

Poly-drug use refers to the use of two or more substances at the one time or repeatedly. It is common among both recreational and regular drug users across the world. Poly-drug use is a great contributor to the global number of deaths related to drug overdose. In this case, the likelihood of drug overdose and its pertaining complications in an individual is higher especially when benzodiazepine...

introduction : clozapine is the first effective antipsychotic drug with the least extra pyramidal side effects and more agranulocytosis than other standard neuroleptics. granolocytopenia or agranulocytosis occurs in 1 to 2 percent of all patients treated with clozapine. agranulocytosis due to clozapine is a fatal disorder that requires immediate clinical intervention.   method : this paper repo...