نتایج جستجو برای: dihydropyridines

تعداد نتایج: 1708  

2008
T Suresh S K Swamy V M Reddy Ch. Ravi Shankar

Thirty five different 4-aryl-1-substituted 2,6-dimethyl-3, 5-bis-N-[(substituted) carbamoyl] 1,4-dihydropyridines have been prepared from a three component condensation reaction of N-(2-chlorophenyl)-acetoacetamide; an aromatic aldehyde and a primary amine under four different experimental conditions. Except for conventional, all the experimental conditions are simple, eco-friendly, economical,...

2010
Santos Fustero María Sánchez-Roselló Carlos del Pozo

The use of domino and multicomponent reactions in asymmetric synthesis is constantly increasing nowadays. This allows for the synthesis of complex molecules in a single synthetic sequence, usually with high atom economy. Herein, we report three examples of new asymmetric tandem reactions recently developed in our laboratories, giving rise to new families of enantiomerically enriched fluorinated...

Journal: :Open Journal of Synthesis Theory and Applications 2018

2017
Alexey M Starosotnikov Dmitry V Shkaev Maxim A Bastrakov Ivan V Fedyanin Svyatoslav A Shevelev Igor L Dalinger

4-Aza-6-nitrobenzofuroxan (ANBF) reacts with 1,3-dicarbonyl compounds and other CH acids to give carbon-bonded 1,4-adducts - 1,4-dihydropyridines fused with furoxan ring. In the case of most acidic β-diketones, which exist mainly in the enol form in polar solvents, the reactions proceed in the absence of any added base emphasizing the highly electrophilic character of ANBF. The resulting compou...

Journal: :Current opinion in pharmacology 2001
T P Snutch K G Sutton G W Zamponi

The blockade of L-type calcium channels by dihydropyridines, phenylalkylamines and benzothiazepines has been well described and forms the basis of a multibillion dollar market for the treatment of cardiovascular disease and migraine. More recently, neuron-specific calcium channels have become the subject of intense interest regarding their potential as therapeutic targets for the treatment of c...

Journal: :The Journal of General Physiology 1997
Vladimir Avdonin Erwin F. Shibata Toshinori Hoshi

Dihydropyridines (DHPs) are well known for their effects on L-typed voltage-dependent Ca2+ channels, However, these drugs also affect other voltage-dependent ion channels, including Shaker K+ channels. We examined the effects of DHPs on the Shaker K+ channels expressed in Xenopus oocytes. Intracellular applications of DHPs quickly and reversibly induced apparent inactivation in the Shaker K+ mu...

F. F. Farzaneh

V2O5/SiO2 nanoparticles was prepared via an one-pot sol gel method from vanadyl- acetylacetonate and tetraethylorthosilicate in refluxing MeOH, followed by calcination at 700 °C for 2 hours. The resultant nanoparticles was characterized by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), TGA and FTIR techniques. Rapid and efficient ar...

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