Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available anti-androgens target only ligand binding, either by reduction of available hormone or by competitive antagonism. New strategies are needed, and could have an important impact on therapy. One approach could be to target other cell...

A 6-year-old girl presented to the emergency department after experiencing genital pain, which had lasted for a few hours, in the middle of the night. A physical examination revealed a moving filamentous object (length: about 7 mm) on her external genitalia. The sharp pain disappeared when the object was removed. By using light microscopy, it was identified as an ovulating female pinworm that h...

The decreasing cost of genomic technologies has enabled the molecular characterization of large-scale clinical disease samples and of molecular changes upon drug treatment in various disease models. Exploring methods to relate diseases to potentially efficacious drugs through various molecular features is critically important in the discovery of new therapeutics. Here we show that the potency o...

A steady increase in the number of dogs in urban areas induced contamination public places with dogs faeces and eggs of zoonotic parasites which present a significant health problem from human. In order to solve the problem most effective way is the eradication parasites of dogs. Our survey we conducted in cooperation with several veterinary clinics in Belgrade in 2015. In total, 223 dogs using...

Mucosal biofilm-related fungal infections are very common, and the incidence of recurrent oral and vulvovaginal candidiasis is significant. As resistance to azoles (the preferred treatment) is occurring, we aimed at identifying compounds that increase the activity of miconazole against Candida albicans biofilms. We screened 1,600 compounds of a drug-repositioning library in combination with a s...

A survey of 108 individuals from a coastal Aboriginal community in north Western Australia revealed that two species of gastrointestinal protozoan parasites (Giardia duodenalis--39.8%, Entamoeba coli--40.7%) and five gastrointestinal helminths (Hymenolepis nana--54.6%, Hookworm [Ancylostoma duodenale]--30.6%, Enterobius vermicularis--6.5%, Trichuris trichiura--2.8%, Strongyloides stercoralis 1....