In this issue, Chiodini and colleagues (1) measured the prevalence of subclinical hypercortisolism in 219 consecutive patients 44 to 72 years of age with suspected idiopathic osteoporosis. These individuals had no known secondary cause of osteoporosis, had not received drugs known to influence bone or cortisol, and had no apparent signs or symptoms of cortisol excess (including moon facies, red...

Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for m...

368 If you are going for it, I certainly would go in for it hard. Halfway measures never got anybody anywhere. – Letter from Harvey Cushing to his son Bill regarding his son's intention to join the Yale varsity hockey team. O n a Saturday morning in 1926, Dr Harvey Cushing, chief and professor of surgery at Harvard's Peter Bent Brigham Hospital, operated meticulously on a young woman with a bra...

To those who were fortunate enough to be present at the seventieth birthday party held for Dr. Cushing by the Harvey Cushing Society in New Haven, April 8, 1939, this little book will remain a precious and cherished memento; to those friends and former pupils of Dr. Cushing not there for that gay and happy occasion it will be an especially coveted treasure-a last visit with "the Chief"; and to ...

OBJECTIVE To report a meta-analysis of late-night salivary cortisol testing for the diagnosis of Cushing syndrome. METHODS MEDLINE and EMBASE computer databases were searched to identify relevant articles published between January 1950 and December 2007. The search strategy used the following medical subject headings and keywords: cortisol, Cushing or Cushing's, saliva, salivary, late-night, ...

El objetivo de este trabajo fue resaltar la importancia del diagnóstico causa síndrome Cushing, en un paciente canino macho, 12 años edad, con carcinoma cortical adrenal, que llega a consulta por presentar signos clínicos compatibles Síndrome Cushing. Los resultados estimulación ACTH sintética (Synacthen 0.25 mg®) arrojaron aumento el cortisol basal (10.8 µg/dl) y pos-estimulación (28.4 µg/dl)....