background chronic rhinosinusitis (crs) and asthma are among the most important health-related conditions with evident socio-economic effects. the relationship between asthma and crs has been considered in medical references for centuries. previous studies have shown that treatment interventions targeting disease in one part of the airway are effective for general asthma management. however, th...

introduction: chronic rhinosinusitis (crs) is a multifactorial disease. allergies are considered a predisposing factor to crs; however, this remains controversial. the objective of this research was to investigate the prevalence of co-morbidities and allergic reaction, and to specify the most common allergens in patients with confirmed crs.   materials and methods: one hundred patients with sig...

BACKGROUND Cytoreductive surgery (CRS)/hyperthermic intraperitoneal chemotherapy (HIPEC) is the procedure of choice in patients with peritoneal dissemination from appendiceal cancer. Although recurrence rates are 26%-44% after first CRS/HIPEC, the role of repeated CRS/HIPEC has not been well defined. We hypothesize that patients undergoing multiple CRS/HIPEC's have meaningful long term survival...

In this paper, we study the relationship between the approximability and the parameterized complexity of NP optimization problems. We introduce a notion of polynomial fixed-parameter tractability and prove that, under a very general constraint, an NP optimization problem has a fully polynomial time approximation scheme if and only if the problem is polynomial fixed-parameter tractable. By enfor...

BACKGROUND The use of drug combinations has revolutionized the treatment of HIV but there is no equivalent combination product that exists for prevention, particularly for topical HIV prevention. Strategies to combine chemically incompatible agents may facilitate the discovery of unique drug-drug activities, particularly unexplored combination drug synergy. We fabricated two types of nanopartic...

Abstract Background Depending on their distinct properties, titanium dioxide nanoparticles (TiO 2 -NPs) are manufactured extensively and widely present in our daily necessities, with growing environmental release public concerns. In sunscreen formulations, supplementation of TiO -NPs may reach up to 25% (w/w). Ocular contact occur accidentally certain cases, allowing undesirable risks human vis...

Introduction In line with the regional aim of eliminating rubella and congenital rubella syndrome (CRS), phased introduction of rubella-containing vaccines (RCV) in the Philippines' routine immunization programme began in 2010. We estimated the burden of CRS in the country before widespread nationwide programmatic RCV use. Methods We performed a retrospective chart review in four tertiary hos...

Bone cement is widely used in surgical treatments for the fixation for orthopaedic devices. Subsequently, 2-3% of patients undergoing these procedures develop infections that are both a major health risk for patients and a cost for the health service providers; this is also aggravated by the fact that antibiotics are losing efficacy because of the rising resistance of microorganisms to these su...

A pattern (i. e., a string of variables and terminals) maps to a word, if this is obtained by uniformly replacing the variables by terminal words; deciding this is NP-complete. We present efficient algorithms1 that solve this problem for restricted classes of patterns. Furthermore, we show that it is NP-complete to decide, for a given number k and a word w, whether w can be factorised into k di...

Rubella infection in pregnancy can lead to pathologies, including miscarriage, stillbirth and congenital rubella syndrome (CRS) in the neonate. Rubella vaccination can prevent all occurrences of CRS. In Sri Lanka, significant outbreaks of CRS occurred in 1994 and 1995, with 275 and 212 reported cases. In 1996, Sri Lanka introduced rubella vaccination for women aged 16-44 years, to stop CRS. Mea...