neurocysticercosis, is the infection caused by the larval form of the tapeworm taenia solium. it is considered as the most common parasitic disease of the central nervous system and the most common cause of acquired epilepsy. this has primarily been a disease that remains endemic in countries with poor economy , but because of increased migration neurocysticercosis is being diagnosed more frequ...

abstract objective tumors of the central nervous system constitute the largest group of solid neoplasms in children and are second only to leukemia in their overall frequency during childhood. the main purpose of the present study is to determine the incidence, age, sex, location and histological diagnosis of cns tumors in children, less than 15 years of age, in the mofid children's hospital, i...

Abstract Background Glioblastoma (GBM) is the most common malignant primary central nervous system (CNS) tumor. It a fast-growing and extremely aggressive malignancy with short postoperative survival time of little more than year. The tumor-immune interactions are complex can be measured as local phenomena - e.g., tumor-infiltrating lymphocytes, or systemic events lymphopenia, neutropenia, etc....

We reviewed the correlation between malignant cells in cerebrospinal fluid (CSF) (positive cytology) and pathologic findings at autopsy. The purpose was to discover: (1) the incidence of negative CSF cytology in patients with CNS malignancy, (2) the incidence of false-positive cytology, and (3) the relationship between a true-positive cytology and the distribution of malignant tumor at autopsy....

background: as children comprise a considerable proportion of our population, the importance of local epidemiologic research and geographic and racial differences can’t be disputed on childhood malignancies. methods: in this descriptive retrospective study, we extensively reviewed the medical records of patients younger than 15 years of age, diagnosed with solid malignant tumors, from 1996 to 2...

Abstract BACKGROUND Integrative brain tumour diagnostics indisputably requires comprehensive reporting of molecular markers. The 2021 WHO classification central nervous system (CNS) tumours substantially increased the set markers for routine evaluation, with greater significance to DNA methylation analysis in diagnostics. Limited by investment and batching, smaller labs clinics might suffer maj...

The development of effective immunotherapeutic strategies for central nervous system (CNS) tumors requires a firm understanding of factors regulating the trafficking of tumor antigen-specific CTLs into CNS tumor lesions. Using C57BL/6 mice bearing intracranial (i.c.) ovalbumin-transfected melanoma (M05), we evaluated the efficacy and tumor homing of i.v. transferred type 1 or 2 CTLs (Tc1 or Tc2...

Central nervous system (CNS) cancers are the second most frequent malignancy in childhood and the most common solid tumor in this age group. In recent years, significant advances in surgery, radiotherapy, and chemotherapy have favorably impacted survival for children with these tumors. However, a significant proportion of patients with CNS tumors suffer progress disease despite such treatment. ...

Extragonadal germ cell tumors are extremely rare and account for only 3%-5% of all germ cell tumors. These tumors are rarely associated with metachronous primary testicular germ cell tumors. We report the fourth case of a primary germ cell tumor occurring after the treatment of a primary CNS germ cell tumor in a 27 year-old male with embryonal cell carcinoma of the testicle 9 years after the tr...

This review article outlines the current development of emerging treatment strategies for primary central nervous system lymphoma, a rare brain tumor with, thus far, limited therapeutic options. Small molecule targeted tyrosine kinase inhibitors, immunomodulatory agents, and immune checkpoint inhibitors will be discussed. The mechanisms action, results completed clinical studies, ongoing trials...