Triboelektrostatická separácia minerálnej substancie zo slovenského uhlia V článku sú diskutované niektoré technické aspekty triboelektrostatickej separácie a výsledky aplikácie tohto postupu pri úprave troch typov uhlia, konkrétne energetického uhlia z Cígľa, Handlovej a Novák. Bolo zistené, že účinnosť separácie veľmi úzko závisí na druhu separovan uhlia. Prvé výsledky preukázali súvislosť me...

CNG repeats (where N denotes one of the four natural nucleotides) are abundant in the human genome. Their tendency to undergo expansion can lead to hereditary diseases known as TREDs (trinucleotide repeat expansion disorders). The toxic factor can be protein, if the abnormal gene is expressed, or the gene transcript, or both. The gene transcripts have attracted much attention in the biomedical ...

Cyclic nucleotide-gated (CNG) channels play a pivotal role in phototransduction. Mutations in the cone CNG channel subunits CNGA3 and CNGB3 account for >70% of all known cases of achromatopsia. Cones degenerate in achromatopsia patients and in CNGA3(-/-) and CNGB3(-/-) mice. This work investigates the molecular basis of cone degeneration in CNG channel deficiency. As cones comprise only 2-3% of...

This paper presents an experimental study of a 4-cylinder, downsized and boosted, spark ignition engine fuelled by either directly injected compressed natural gas (DI CNG) or gasoline (GDI). Three different charge preparation strategies are investigated for both fuels: stoichiometric operation without external dilution, with exhaust recirculation (EGR) lean burn. The performance the optimized D...

Road transportation has received the attention of researchers due to its higher carbon footprint. Alternative fuels present major advantages in terms environmental sustainability. For this reason, an enviro-economic analysis alternative carries great significance. However, scarce attempts have been rendered order ascertain impact a hydroxy gas (HHO) and compressed natural (CNG) mixture on susta...

The rd1 natural mutant is one of the first and probably the most commonly studied mouse model for retinitis pigmentosa (RP), a severe and frequently blinding human retinal degeneration. In several decades of research, the link between the increase in photoreceptor cGMP levels and the extremely rapid cell death gave rise to a number of hypotheses. Here, we provide clear evidence that the presenc...

Cyclic nucleotide-gated (CNG) channels conduct NaF, KF and Ca2F currents under the control of cGMP and cAMP. Activation of CNG channels leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2F concentration. Several polypeptides were identified that constitute principal and modulatory subunits of CNG channels in both neurons and non-excitable cells, co...

The response of cone photoreceptors to light is stable and reproducible because of the exceptional regulation of the cascade of enzymatic reactions that link visual pigment (VP) excitation to the gating of cyclic GMP (cGMP)-gated ion channels (cyclic nucleotide-gated [CNG]) in the outer segment plasma membrane. Regulation is achieved in part through negative feedback control of some of these re...

In mammals, the master circadian clock resides in the suprachiasmatic nuclei (SCN) of the hypothalamus. The period and phase of the circadian pacemaker are calibrated by direct photic input from retinal ganglion cells (RGCs). SCN-projecting RGCs respond to light in the absence of rod- and cone-driven synaptic input, a property for which they are termed intrinsically photosensitive. In SCN-proje...

RATIONALE We have shown recently that particulate (pGC) and soluble guanylyl (sGC) cyclases synthesize cGMP in different compartments in adult rat ventricular myocytes (ARVMs). OBJECTIVE We hypothesized that cGMP-dependent protein kinase (PKG) exerts a feedback control on cGMP concentration contributing to its intracellular compartmentation. METHODS AND RESULTS Global cGMP levels, cGMP-phos...