Cholinesterase (ChE) is a group of enzymes that hydrolyze cholinester. There are two ChE isoenzymes in the blood, namely Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). Both required process sending nerve signals. The activity these will be decreased by exposure to toxic chemical agents, insecticides such as organophosphates or carbamates, anesthetic drug therapy for Alzheimer’s d...

In this research, we synthesized oxazine and thiazine derivatives (3-6). These of chacone compounds (1 2) that from 4- hydroxyacetophenone aldehyde such as, 4-bromobenzaldehyde chlorobenzaldehyde. chalcone (1-2) reacted with urea to produce as 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-oxazin-2-yl] phenol (3 4) thiourea 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-thiazin-2-yl] (5 6). were characteri...

Alzheimer's disease (AD), a multifaceted neurological ailment that progresses over time, is the most common cause of dementia in older people. Intracellular neurofibrillary tangles and extracellular amyloidal protein deposits contribute to senile plaques on pathological level. AD symptoms vary depending stage disease. Depending severity cognitive impairment, classified as preclinical or presymp...

The effect of temperature on the inhibition of serum cholinesterase by dibucaine, fluoride and chloride has been studied. It is found that the dibucaine and chloride numbers together are capable of differentiating the inherited enzyme variants at 30° and 37°C. Fluoride numbers contribute little information at these temperatures; indeed fluoride inhibition is so sensitive to temperature change t...

Alzheimer’s Disease (AD) is a disorder that causes degeneration of the cells in brain and it main cause dementia, which characterized by decline Independence an individual’s daily activities. AD considered multifactorial disease. Two hypotheses have been proposed as AD. The cholinergic hypothesis amyloid hypothesis. In addition, several risk factors implicated this disease, including aging, gen...

Thirty derivates from substituted-phenyl-ethyl methylphosphonates have been synthesized and their inhibiting power of acetyl-cholinesterase have been examined in vitro and in vivo. The correlation between inhibition of the enzyme and electrophylic power of the substituent of the phenyl group was excellent, but when this group contains two substituents, steric factors appear to operate. The acti...

Frog skin cholinesterase is largely of the serum (pseudocholinesterase) type. For whole skin, the activity at 10(-1) AcChCl is 4.9 microl./mg. N/hr. Tela subcutanea isolated by dissection exhibits an activity of 65 microl./mg. N/hr. at 10(-1) AcChCl. Since about one-tenth of the nitrogen of the skin is located in the tela subcutanea, it is estimated that more than 90 per cent of the enzyme is a...

Organophosphate (OP) poisoning is one of the most common toxicological emergencies, especially in developing countries. They work by inhibiting cholinesterase enzyme lead to severe cholinergic toxicities. Organophosphorus intoxication occurs after cutaneous exposure, respiratory inhalation or gastrointestinal tract absorption. Exposure to organophosphate and other agents increases yearly, with ...

Background: Organophosphorus compound ingestion is one of the most common modes of deliberate self-harm in developing countries like India. Neurological complications are known in acute, intermediate and delayed phases following organophosphate poisoning. However, extrapyramidal manifestations are rarely reported. Case presentation: A 30-year-old male patient was brought...