Aim: To study the effect of palm oil and Nigella sativa on the aorta and coronary arteries of albino rats. Methods: Sixty albino rats including equal number of males and females were obtained from PCSIR Laboratories, Lahore. After overnight fasting of 12-14 hour all the animals were weighed and zero and 24 weeks. The rats were divided into five groups of twelve animals each. Each group had six ...

The association between accumulation of oxidized low density lipoprotein (LDL) and (1) progression of atherosclerotic plaques and (2) compensatory enlargement was assessed in the coronary arteries of LDL-hypercholesterolemic miniature pigs. In miniature pigs fed a 4% cholesterol diet, LDL cholesterol levels increased from 2763.5 mg/dL (mean6SEM, n536) to 250628 mg/dL (n510), 260615 mg/dL (n56),...

BACKGROUND The inflammatory/antiinflammatory properties of HDL were compared with HDL cholesterol in 2 groups of patients and in age- and sex-matched control subjects. METHODS AND RESULTS Group 1 consisted of 26 patients not yet taking a statin who presented with coronary heart disease (CHD) or CHD equivalents by National Cholesterol Education Program Adult Treatment Panel III criteria studie...

We studied the short-term effects of a 20% coconut oil supplementation to the chick diet on lipid composition of liver and hepatic mitochondria, and changes that occurred in mitochondrial-associated enzymes as a result of this diet. No significant differences were observed in the lipid contents of liver when young chicks were fed the experimental diet, whereas hepatic mitochondria rapidly chang...

Objectives. Reduction in serum lipoproteins, especially LDL cholesterol, is a preventive approach against atherosclerosis. Bloodletting has been a recommended method to reduce serum lipoprotein concentrations. Present study was conducted to investigate the effects of wet cupping as a method of bloodletting on serum lipoproteins. In a randomized controlled trial, 47 men, 18-25 years old, without...

Gingerols, the pungent ingredients in ginger, are reported to possess a cholesterol-lowering activity. However, the underlying mechanism remains unclear. The present study was to investigate how 6-gingerol (6-GN), the most abundant gingerol in fresh ginger, regulates hepatic cholesterol metabolism. HepG2 cells were incubated with various concentrations of 6-GN ranging from 50 to 200 μM for 24 h...

Rhesus monkeys were fed high cholesterol and cholesterol-free diets for 21-24 months. The animals were then given isotopic cholesterol intravenously and autopsied from 1 to 51 weeks later. The plasma and aortic cholesterol contents were 633 +/- 130 mg/dl and 35.6 +/- 11.4 mg/g dried tissue (45.5% in ester form) for atherosclerotic monkeys and 135 +/- 25 mg/dl and 9.9 +/- 3.6 mg/g (15.0% in este...

We examined the effects of dietary cholesterol (less than 0.01 and 1.7 mg/Kcal) and type of fat (saturated, coconut oil; polysaturated, corn oil) on very low density plus low density lipoprotein (VLDL + LDL) and high density lipoprotein (HDL) cholesterol in 24 young baboons (12 male, 12 female) Paplo sp.) in a crossover design experiment. The oils contributed 40% of calories. Total serum choles...

Patients with homozygous familial hypercholesterolaemia (HoFH) have markedly elevated low density lipoprotein (LDL) cholesterol levels that are refractory to standard doses of lipid-lowering drug therapy. In the present study we evaluated the effect of atorvastatin on steady state concentrations of plasma lipids and mevalonic acid (MVA), as well as on 24-h urinary excretion of MVA in patients w...