This paper proposes a novel protein micro arrayer employing 3-in-1 chip system, instantly delivering hundreds of biosamples in parallel for disease diagnosis. The 3-in-1chip system included: micro filling chip, micro stamper array and micro bio-reaction chip, applicable to high throughput disease diagnosis and drug screening. Capillary force is applied to drive liquids flowing through all the c...

Dorso-ventral axis formation in the Drosophila wing requires the localized accumulation of the Apterous LIM/homeodomain protein (Ap) in dorsal cells. Here we report that dLdb/Chip encodes a LIM-binding cofactor that controls Ap activity. Both lack and excess of dLdb/Chip function cause the same phenotype as apterous (ap) lack of function; i.e. dorsal to ventral transformations, generation of ne...

For the first time, the 4- and 5-port optical routers are designed by using the West First routing algorithm for use in optical network on chip. The use of the WF algorithm has made the designed routers to provide non-blocking routing in photonic network on chip. These routers not only are based on high speed Mach-Zehnder switches(Which have a higher bandwidth and more thermal tolerance than mi...

The finite element modeling and experimental validation of 3D turning of grade two commercially pure titanium are presented. The Third Wave AdvantEdge machining simulation software is applied for the finite element modeling. Machining experiments are conducted. The measured cutting forces and chip thickness are compared to finite element modeling results with good agreement. The effects of cutt...

In machining of Ti-6Al-4V alloy, the formation of saw tooth chips takes place at relatively low cutting speeds in comparison to other materials such as hardened steels. Study of chip morphology is important to understand the cutting force variation, surface integrity and chip breakability of the alloy. In this work, an attempt has been made to study the effect of cutting speed, feed rate and de...

In the present investigation, numerical models that accurately predict the chip formation and stress profiles in the work-piece during orthogonal metal cutting were developed using the explicit finite-element method (FEM). More specifically, a damage material model was utilized to capture the work-piece chip formation and simultaneous breakage of the chip into multiple fragments. In the simulat...

Trans-epithelial electrical resistance (TEER) is broadly used as an experimental readout and a quality control assay for measuring the integrity of epithelial monolayers cultured under static conditions in vitro, however, there is no standard methodology for its application to microfluidic organ-on-a-chip (organ chip) cultures. Here, we describe a new microfluidic organ chip design that contain...

Most of the materials used in the industry of aero-engine components generally consist of titanium alloys. Advanced materials, because of their excellent combination of high specific strength, light weight and general corrosion resistance. In fact, chemical wear resistance of aero-engine alloy provides a serious challenge for cutting tool material during the machining process. The reduction in ...

Protein misfolding is a common event in living cells. Molecular chaperones not only assist protein folding; they also facilitate the degradation of misfolded polypeptides. When the intracellular degradative capacity is exceeded, juxtanuclear aggresomes are formed to sequester misfolded proteins. Despite the well-established role of chaperones in both protein folding and degradation, how chapero...