Although there are some newly developed options to treat dystonia, its medical treatment is not always satisfactory. Zolpidem, an imidazopyridine agonist with a high affinity on benzodiazepine subtype receptor BZ1 (ω1), was found to improve clinical symptoms of dystonia in a limited number of case reports. To investigate what subtype of dystonia is responsive to the therapy, we conducted an ope...

Purpose: The aim of this study to examine the in changes inhibitory interneurons brainstem, which are likely be involved pathophysiology cervical dystonia, using cutaneous silent period(SP) method is an inhibitor reflex.
 Materials and Methods: SP latency interval values were obtained from bilateral sternocleidomastoid (SCM) muscles individuals 20 patients with dystonia 25 healthy voluntee...

OBJECTIVE To investigate the feasibility and effectiveness of an active exercise program for cervical dystonia. DESIGN Pilot randomized controlled, single-blind trial of a 12-week intervention followed by a four-week follow-up period. SETTING Supervised physiotherapy and outcome measurement sessions were conducted in a hospital outpatient physiotherapy setting. Participants also performed e...

The sternocleidomastoid muscle (SCM) is one of the major muscles involved in producing abnormal head position in cervical dystonia patients. This study tested whether doxorubicin chemomyectomy, direct injection of doxorubicin into the SCM to permanently remove muscle fibers, has the potential to be a nonsurgical, permanent treatment for cervical dystonia. The right SCM of rabbits was injected w...

BACKGROUND A registry of patients with cervical dystonia (Cervical Dystonia Patient Registry for Observation of onaBotulinumtoxinA Efficacy [CD PROBE]) was initiated to capture data regarding physician practices and patient outcomes with onabotulinumtoxinA (BOTOX®, Allergan, Inc., Irvine, CA, USA). Methods and baseline demographics from an interim analysis are provided. METHODS/DESIGN This is...