In this work, the effect of cellulosic polymer and chemical structure of salicylic acid and its various esters on their release has been analysed. The release of different drugs in distinct types of vehicles, cetyl excipient, polyethylene glycol and Carbopol gel was also studied.  2001 Published by Elsevier Science B.V.

INTRODUCTION As a topical delivery system, a nanoscaled emulsion is considered a good carrier of several active ingredients that convey several side effects upon oral administration, such as nonsteroidal anti-inflammatory drugs (NSAIDs). OBJECTIVE We investigated the in vitro permeation properties and the in vivo pharmacodynamic activities of different nanoscaled emulsions containing ibuprofe...

Intranasal administration is an ideal alternative to the parenteral route for systemic drug delivery. Various conventional dosage forms have been employed for this purpose but they lack to provide the desired bioavailability of the drug due to poor residence time and faster clearance in the nasal cavity. Formulating multiparticulate system with mucoadhesive polymers may provide a significant in...

Purpose: To formulate topical gels containing various essential oils and evaluate their antibacterial activity against methicillin-resistant Staphylococcus Aureus (MRSA) skin infections. Methods: The four essential oils namely, lemon grass, rosemary, thyme and basil were steam-distilled and then evaluated for their antibacterial activity against MRSA. Lemon grass and thyme oils were chosen for ...

OBJECTIVES The objective of this study was to elucidate the safety and effectiveness of acemannan, a polysaccharide extracted from Aloe vera, in the treatment of oral aphthous ulceration. DESIGN A skin patch test was performed on 100 healthy subjects, and 0.5% acemannan in Carbopol® 934P NF (Lubrizol Corporation, USA) was applied to the oral mucosa of the lower lip of 50 healthy participants ...

Naproxen sodium is a non steroidal antiinflammatory drug, used in the treatment of inflammatory and degenerative disorders of the musculoskeletal system. It is widely prescribed for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, extra-articular disorders, bursitis, tendonitis, and non articular rheumatic condition. Naproxen sodium has some side effects when...

Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The main objective is to formulate and evaluate in situ oral topical gels of clotrimazole based on the concept of pH triggered and ion activated systems. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific phy...

Conventional ophthalmic solutions often eliminate rapidly after administration and can’t provide and maintain an adequate concentration of drug in the precorneal area. This can be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the culde-sac. The present work describes the formulation and evaluation of an ophthalmic...