The regulation of energy homeostasis is fundamental to all organisms. The Drosophila fat body serves as a repository for both triglycerides and glycogen, combining the energy storage functions of mammalian adipose and hepatic tissues, respectively. Here we show that mutation of the Drosophila adipokinetic hormone receptor (AKHR), a functional analog of the mammalian glucagon receptor, leads to ...

In recent years biodiesel production has attracted worldwide attention due to the awareness of fossil fuel depletion and microalgae biomass is considered a promising raw material for its formulation. The present study evaluated effects different levels nitrogen limitation (37.5, 18.75, 9.375 mg L−1 NaNO3) on growth, cell ultrastructure, biochemical composition halophilic native strain green alg...

Peters and Sinclair (1933) have shown that in pigeons suffering from vitamin-B, deficiency the brain, when incubated with lactic acid, produced pyruvic acid in appreciable amount whereas when the brain of normal control birds is substituted this is not produced. Peters and Thompson (1934) further showed that pyruvic acid is probably a normal intermediary in the course of carbohydrate metabolism...

Leftover dough, a byproduct in steamed bread processing, is rich starch, which carbohydrate source for microorganisms. Carbon and nitrogen are the two most abundant nutrients medium of Isochrysis galbana. In this study, leftover dough hydrolysates were used as carbon resources cultivation galbana docosahexaenoic acid production under different NaNO3 concentrations. The results showed that conce...

A chemical method of deglycosylation of human choriogonadotropin (hCG) was used to assess the role of carbohydrate moiety in the maintenance of quaternary structure and functional parameters such as receptor binding, immunological activity, and in vitro biological response. Treatment of purified hCG with anhydrous HF at 0 degrees C for 60 min was effective in removing more than 75% of the carbo...

Glycogen synthase (GS) activity was characterized in rat brown adipose tissue (BAT) and the activity was found to be much higher than that in white adipose tissue. Prolonged starvation had no effect on the active form of GS, as found in the liver and muscle. The GS activity was similar in BAT of rats housed in an animal room (21 +/- 1 degree) whether they were fed on high-carbohydrate, high-fat...

The synthesis and in vitro cytotoxicity of a series of Ru(II)(arene) complexes with carbohydrate-derived phosphite ligands and various arene co-ligands is described. The arene ligand has a strong influence on the in vitro anticancer activity of this series of compounds, which correlates fairly well with cellular accumulation. The most lipophilic compound bearing a biphenyl moiety and a cyclohex...

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a paramount role in the degradation of low-density lipoprotein (LDL) receptors (LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol (LDL-c) levels. The anti-PCSK9 monoclonal antibodies lead to substantial decrease of LDL-c concentration. PCSK9 (which is also expressed in pancreatic d...