objective: it is generally agreed that most of the phenomena observed during brain ischemia and reperfusion can be explained by the damage to membrane structure. oxidative stress is resulted in an imbalance between high consumption of oxygen and low levels of endogenous antioxidants. it is known that gallic acid (ga) is a strong antioxidant. the present study was carried out to evaluate the eff...

objective: to determine the prediction value of disorder of consciousness scale (docs) for consciousness recovery after traumatic brain injury (tbi) leading to coma. methods: this is a descriptive-cross-sectional study of the correlation between the level of patients’ consciousness in the first and second weeks and the first 2 months after traumatic brain injury, using docs scale. results: the ...

conclusions the findings of this study indicated that the economic burden of tbis was high in fatal accidents in fars province so that it was equivalent to 0.00011% of iran’s gross domestic product (gdp) in 2013. therefore, more attention has to be paid to the rules to prevent the fatal accidents. results deaths resulting from tbis due to traffic accidents in shiraz imposed 6.2 billion rials (5...

a motor vehicle seat belt use law for the driver and front-seat passenger was implemented in taiwan on june 1, 2001. the purpose of this study was to determine the effect of motor vehicle seat belt use on the severity of traumatic brain injuries because of motor vehicle accidents.data were collected from 27 major teaching hospitals four years before june 1, 2001 and until may 31, 2013. a total ...

a neurological disorder is any disorder of the nervous system is usually due to cell loss. the ultimate goal of cns therapy is to replace lost cells and tissue. there is no neuroprotective, pharmacological and effective treatment available that restores the injury-induced loss of function. recent studies suggest that identification of adult neural stem/progenitor cells indwelling in the neuroge...

traumatic brain injuries may cause some neurological deficits, such as altered level of consciousness or coma, sensory-motor dysfunction, and seizure attacks. the neuroprotective effect of progesterone and erythropoietin has been shown in different types of brain injuries and cerebral ischemia. this study aims to evaluate the probable additional neuroprotective effects of progesterone and eryth...

Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma. Cell therapy may provide a promising treatment for TBI. Human neural stem cells cultured in self-assembling peptide scaffolds have been proposed as a potential novel method for cell replacement treatment after TBI. In the present study, we accessed the effects of human neural stem/progenitor cells (hNS/...

Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...