BACKGROUND Amoxicillin is a commonly used antibiotic which has a short half-life in human. The frequent administration of amoxicillin is often required to keep the plasma drug level in an effective range. The short dosing interval of amoxicillin could also cause some side effects and drug resistance, and impair its therapeutic efficacy and patients' compliance. Therefore, a three-pulse release ...

This paper discusses the use of Box Behnken design (BBD) approach to plan the experiments for turning the yield of CVD, thickness and layer number of graphene sheets with an overall objective of optimizing the process to provide higher graphene production volume, fewer layers and thinness structure of graphene. BBD is having the maximum efficiency for an experiment involving four factors such a...

The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...

Microwave assisted extraction technique was employed to extract pectin from citron peel. Box-Behnken design was applied to investigate the influence of irradiation time, microwave power and pH on the yield and DE of pectin. The finding indicated that the optimal conditions for the maximum yield of pectin (30.71%) were achieved at irradiation time of 3 min, microwave power of 700 W and pH of 1.5...

The chemical step in the chemoenzymatic synthesis of bioengineered heparin has been examined and optimized statistically using a response surface methodology. A four factor, two level full factorial design experiment and a three factor Box-Behnken design were carried out. The goal was to establish a method to prepare N-sulfo, N-acetyl heparosan of the desired N-acetyl content, number average mo...

A thermosyphon is an efficient heat transfer device, which transports heat using gravity for the evaporation and condensation of the working fluid. In the present study the Box-Benhnken (BBD) design approach was chosen for the Two-Phase Closed Thermosyphon (TPCT) with CeO2 nanofluid using 0.1% volume of Nanofluid with surfactant of ethylene glycol. The experiment resulted in identifying the opt...

In this study, Box-Behnken”s Response Surface Methodology (RSM) was applied to study the esterification reaction effectiveness of acid activated Ngbo clay catalyst. The were monitored based on process conditions temperature, duration, amount reactant, catalyst weight and particle size. Box--Behnken’s indicates that clay-catalysed reactions proceed through dual mechanisms Acid-complex Alcohol-co...