Computer-based structure prediction becomes a major tool to provide large-scale structure models for annotating biological function of proteins. Information of residue-level accuracy and thermal mobility (or B-factor), which is critical to decide how biologists utilize the predicted models, is however missed in most structure prediction pipelines. We developed ResQ for unified residue-level mod...

Article history: The Himalayan orogenic bel Received 27 September 2007 Received in revised form 14 April 2008 Accepted 16 April 2008 Available online 3 May 2008

Mesenchymal stem cells (MSCs) interact with tumor cells and regulate tumorigenesis and metastasis. As one of the important components of the tumor microenvironment, MSC-secreted cytokines play a critical role in cancer development. However, whether and how bone marrow MSCs (BMSCs) and their secreted cytokines participate in hepatocellular carcinoma (HCC) progression, still remains largely unkno...

Background BEL is approved for active SLE and lupus nephritis (adults only). Despite failed trials, 1 RTX remains in the treatment armamentarium. Sequential therapy offers a promising strategy to target B cells by distinct but complementary mechanisms. Objectives To assess pharmacodynamic effects of single cycle on immunologic biomarkers adults with SLE. Methods In this 104-week (wk) study ( NC...

BACKGROUND Osteocalcin (OC) contributes to the process of bone mineralization. Present study was designed to investigate the changes in OC gene expression of postmenopausal women treated with hormone replacement therapy (HRT). Study was also designed to evaluate OC gene expression in cells which are not part of connective tissue. MATERIAL AND METHODS Research was carried out on 30 postmenopau...

In the present studies, a novel compound with potent anti-tumor activity from Ciona intestinalis L. was purified by acetone fractionation, ultrafiltration, gel chromatography and High Performance Liquid Chromatography. The molecular weight of the highly purified compound, designated CI431, was 431Da as determined by HPLC-MS analysis. CI431 exhibited significant cytotoxicity to several cancer ce...

This is a continuing attempt in a series of papers KM 93, Mur 93, Mur 94] to show how computer-represented knowledge can be arranged as elements of an eeectively represented semantic domain in the sense of GS 90]. We present a direct deductive description of the domain, which was deened semantically in KM 93], via the Scott's notion of information system. Also, the internal structure of the con...

For surfaces of revolution B in R, we investigate the limit distribution of minimum energy point masses on B that interact according to the logarithmic potential log(1/r), where r is the Euclidean distance between points. We show that such limit distributions are supported only on the “out-most” portion of the surface (e.g., for a torus, only on that portion of the surface with positive curvatu...

We prove that a completely symmetric and trace-free rank-4 tensor is, up to sign, a Bel-Robinson type tensor, i.e., the superenergy tensor of a tensor with the same algebraic symmetries as the Weyl tensor, if and only if it satisfies a certain quadratic identity. This may be seen as the first Rainich theory result for rank-4 tensors.

We consider the problem of the nature and possible types of spacetime singularities that can form during the evolution of FRW universes in general relativity. We show that by using, in addition to the Hubble expansion rate and the scale factor, the Bel-Robinson energy of these universes we can consistently distinguish between the possible different types of singularities and arrive at a complet...