In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process-from selection of candidate vaccine viruses (CVVs...

The purpose of this paper is to provide a reference for the future stockpiling of drugs and developing vaccines for treatment of emerging infectious diseases by summarizing the status of drug stockpiling, vaccine development, and related policies during three major outbreaks of avian influenza among humans (H5N1 in 2003, H1N1 in 2009, and H7N9 in 2013). Documents regarding drug stockpiling and ...

background and aims: hemagglutinin (ha) protein of avian influenza (ai) plays an essential role in the virus pathogenicity. ai h9n2 subtype causes significant economic loss in broiler and layer in poultry farms in iran. ai viruses have a great involvement in evolutionary changes at nucleotide and amino acid levels and vaccines could induce faster rates of such changes. up-dated understanding of...

ABSTRACT: Objective: To investigate sociodemographic factors associated with the willingness to take pandemic influenza vaccine. Methods: This is a cross-sectional study of Brazilian civil servants participating in fourth wave (2012–2013) longitudinal Pró-Saúde Study. Associations were expressed as odds ratios (OR) and 95% confidence intervals (95%CI), estimated by multivariate logistic regress...

BACKGROUND Influenza virus remains a significant health and social concern in part because of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1 vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, derived from the U.S. military Ad4 vaccine strain, to express the hemagglutinin (HA) gene from A/Vietnam/1194/2004 influenza virus ...

Influenza is a contagious viral disease that is seen in avian, human and other mammals, so its control is important. Vaccination against influenza virus subtype H9N2 is one of the ways in controlling program, for this reason several vaccines has been produced. Recently, application of inactivated oil-emulsion vaccines in poultry for controlling low pathogenic avian influenza is increasing. At p...

Background: Studies have shown that DNA vaccines can induce protective immunity, which demonstrated the high potential of DNA vaccines as an alternative to inactivated vaccines. Vaccines are frequently formulated with adjuvants to improve their release, delivery and presentation to the host immune system. Methods: The H5 gene of H5N1 virus (A/Ck/Malaysia/5858/04) was cloned separately into pcDN...

introduction: influenza can cause more severe diseases and higher rate of morbidity and mortality in the elderly population. therefore, they should receive influenza vaccine annually. however, the host response to vaccine is less in older individuals. on the other hand, selenium can act as a stimulator of the immune system and cause increased immunity and response to vaccine. this study was car...

background : avian influenza virus (aiv) infection is a major cause of bird and human morbidity and mortality. we aimed to evaluate a specific and sensitive multiplex rt-pcr that can simultaneously detect influenza type a viruses and differenti­ate the two most important subtypes of avian influenza viruses h7 and h9 subtypes. methods : a multiplex reverse transcriptase-polymerase chain reaction...

Control measures for H5N1 avian influenza involve increased biosecurity, monitoring, surveillance and vaccination. Subclinical infection in farmed ducks is important for virus persistence. In major duck rearing countries, homologous H5N1 vaccines are being used in ducks, so sero-surveillance using H5- or N1-specific antibody testing cannot identify infected flocks. An alternative is to include ...