There are currently several recommended drug regimens for uncomplicated falciparum malaria in Africa. Each has different properties that determine its impact on disease burden. Two major antimalarial policy options are artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DHA-PQP). Clinical trial data show that DHA-PQP provides longer protection against reinfection, while AL is bette...

AIMS To determine the pharmacokinetics of artemether (ARM) and its principal active metabolite, dihydroartemisinin (DHA) in healthy volunteers. METHODS Six healthy male Malaysian subjects were given a single oral dose of 200 mg artemether. Blood samples were collected to 72 h. Plasma concentrations of the two compounds were measured simultaneously by reversed-phase h.p.l.c. with electro-chemi...

background cellular level of enzyme activity can serve as a reliable biomarker in the event of environmental/chemical insults. objectives the present study investigated time-dependent alterations of erythrocyte glutathione s-transferase (ery-gst) activity of non-malarious guinea pigs (cavia tschudii) administered with pyrimethamine/sulfadoxine and artemether/lumefantrine combination therapies. ...

Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its latest World Health Organization blister formulation. Patients with uncomplicated Plasmodium falciparum malaria were prescribed artemether-lumef...

Aim: Malaria, especially that caused by Plasmodium falciparum, is one of the most important infectious diseases in the world, and its control is hampered by increasing resistance of malaria parasites to available drugs. Case: We report a case of possible clinical failure of artemether-lumefantrine treatment in a 26-year old Tunisian traveler with uncomplicated P. falciparum malaria imported fro...

The efficacy of 3-day regimens of artemether-lumefantrine and artesunate-amodiaquine were evaluated in 747 children < 5 years of age with uncomplicated malaria from six geographical areas of Nigeria. Fever clearance was significantly faster (P = 0.006) and the proportion of children with parasitemia 1 day after treatment began was significantly lower (P = 0.016) in artesunate-amodiaquine-compar...

OBJECTIVE To summarize the existing evidence on the efficacy of artemether and arteether, two artemisinin derivatives, versus quinine for treating cerebral malaria in children. METHODS We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and the http://clinicaltrials.gov web site. We also checked the reference lists of existing systematic reviews and of all trials i...

Abstract Schistosomiasis, a neglected tropical disease, affects millions of lives and accounts for thousands deaths each year. The Schistosoma parasites depend on two hosts during their lifecycle: snails as intermediate human beings definitive hosts. Therefore, to control ultimately eliminate schistosomiasis relies the reduction snail populations well prevention treatment infections. Praziquant...

A new simple, sensitive, precise, and accurate high-performance liquid chromatography (HPLC) method of analysis for artemether both as a bulk drug and in capsule formulations was developed and validated. The method employed mobile phase acetonitrile (ACN) and buffer in the ratio 65:35 of pH 6.5 adjusted with tryethylamine. The linear regression analysis data for the calibration plots showed goo...