We performed in vitro antifungal checkerboard testing on 12 Aspergillus fumigatus clinical isolates (6 transplant recipients and 6 nontransplant patients) with three antifungal agents (amphotericin B, voriconazole, and caspofungin) and three immunosuppressants (FK506, cyclosporine, and rapamycin). We were not able to detect a difference in calcineurin inhibitor antifungal activity against isola...

in this study antibacterial, antifungal and cytotoxic effects of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives have been evaluated. the in vitro antibacterial and antifungal tests of new synthesized compounds were performed using maba method against six strains of bacteria (three gram-positive and three gram-negative) and three strains of fungi. also minimum bactericidal concentrat...

BACKGROUND The incidence and prevalence of serious mycoses continues to be a public health problem. Despite aggressive treatment with new or more established licensed antifungal agents, these infections are an important cause of morbidity and mortality, especially in immunocompromised patients. AIMS To critically review the literature regarding important new developments in the field of antif...

In line with the availability of an increasing array of systemic antifungal agents, there is a need for accurate, reproducible and predictive susceptibility testing of fungal isolates in order to help inform clinical choice. Much early attention on antifungal susceptibility testing focused on defining test parameters that produced reproducible and reliable intra- and inter-laboratory results an...

Medically important fungal infections can be broadly classified into superficial surface infections and invasive mycoses (Samaranayake and MacFarlane, 1990; Roemer and Krysan, 2014). Superficial surface infections include mucosal candidiasis, dermatophyte infections whereas invasive mycoses affect sterile body sites such as bloodstream, central nervous system, kidney, lungs, and liver. Rise of ...

Fungal infections still represent relevant human illnesses worldwide and some are accompanied by unacceptably high mortality rates. The limited current availability of effective and safe antifungal agents makes the development of new drugs and approaches of antifungal vaccination/immunotherapy every day more needed. Among them, small antibody(Ab)-derived peptides are arousing great expectations...

Background: Candidiasis is one of the most common fungal infections in immunosuppressed patients. The condition is usually treated with local and systemic antifungal agents. Given the antifungal properties of propolis, it appears this natural resin material can be effective in treating this infection. The aim of the present in vitro study was to compare the effect of Iranian propolis with those...

Recent increases in fungal infections, the few available antifungal drugs, and increasing fungal resistance to the available antifungal drugs have resulted in a broadening of the search for new antifungal agents. Strains of Pseudomonas syringae pv. syringae produce cyclic lipodepsinonapeptides with antifungal activity. The in vitro antifungal and fungicidal activities of three cyclic lipodepsin...

The development of resistance to current antifungal therapeutics drives the search for effective new agents. The fact that some acetophenone-derived Mannich bases had shown antifungal activities in our previous studies led us to design and synthesize acetophenone-derived bis Mannich bases, B1-B5, bis(beta-aroylethyl)methylamine hydrochlorides, to evaluate their antifungal activity. These bis Ma...

N -myristoyltransferase (NMT) has been an emerging target for the design of novel antifungal agents with new mode of action. A series of furan and imidazole containing heterocyclic derivatives have been designed using rational drug designing approach as NMT inhibitors. Newly Designed compounds were synthesized, characterized and evaluated for their antifungal activity against NMT. Synthesized c...