نتایج جستجو برای: anergy

تعداد نتایج: 1795  

Journal: :Journal of leukocyte biology 2007
M Domínguez-Villar A Muñoz-Suano B Anaya-Baz S Aguilar J P Novalbos J A Giron M Rodríguez-Iglesias F Garcia-Cozar

Hepatitis C virus (HCV) infection is the main cause for chronic hepatitis, leading to cirrhosis and hepatic carcinoma. Virally induced immune dysfunction has been called as the cause for viral persistence. Previous results demonstrate that CD4 Jurkat cells stably expressing the HCV core protein show an increased activation of NFAT transcription factor and an impaired IL-2 promoter activity, aff...

Journal: :Blood 2012
Xuguang Tai François Van Laethem Leonid Pobezinsky Terry Guinter Susan O Sharrow Anthony Adams Larry Granger Michael Kruhlak Tullia Lindsten Craig B Thompson Lionel Feigenbaum Alfred Singer

CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. In the present study, we assessed CTLA-4 protein function in both Tregs and conventional (Tconv) CD4(+) T cells. We report that CTLA-4 proteins are responsible for all 3 characteristic Treg functions of suppression, TCR hyposignaling, and an...

Journal: :Journal of immunology 1998
Y Pewzner-Jung D Friedmann E Sonoda S Jung K Rajewsky D Eilat

To study the relative contributions of clonal deletion, clonal anergy, and receptor editing to tolerance induction in autoreactive B cells and their dependence on B cell receptor affinity, we have constructed "knock in" mice in which germline encoded or somatically mutated, rearranged anti-DNA heavy (H) chains were targeted to the H chain locus of the mouse. The targeted H chains were expressed...

Journal: :Journal of immunology 2007
Boris Alabyev Ziaur S M Rahman Tim Manser

The peripheral B cell compartment contains high levels of "polyreactivity" including autospecificities. We have described a pathway that certain autoreactive B cells may take in gaining stable access to the foreign Ag-responsive peripheral compartment. This pathway was revealed in mice expressing a targeted Ig H chain transgene encoding BCRs with "multireactivity" for the hapten arsonate and DN...

Journal: :Journal of immunology 2013
Simanta Pathak Shibin Ma Vipul Shukla Runqing Lu

B cell central tolerance is a process through which self-reactive B cells are removed from the B cell repertoire. Self-reactive B cells are generally removed by receptor editing in the bone marrow and by anergy induction in the periphery. IRF8 is a critical transcriptional regulator of immune system development and function. A recent study showed that marginal zone B cell and B1 B cell populati...

Journal: :Journal of immunology 2001
M N Avice M Rubio M Sergerie G Delespesse M Sarfati

We recently reported that CD47 ligation inhibited IL-2 release by umbilical cord blood mononuclear cells activated in the presence of IL-12, but not IL-4, preventing the induction of IL-12Rbeta(2) expression and the acquisition of Th1, but not the Th2 phenotype. Here we show that in the absence of exogenous cytokine at priming, CD47 ligation of umbilical cord blood mononuclear cells promotes th...

Journal: :Blood 2009
Ian A Parish Sudha Rao Gordon K Smyth Torsten Juelich Gareth S Denyer Gayle M Davey Andreas Strasser William R Heath

Peripheral tolerance induction is critical for the maintenance of self-tolerance and can be mediated by immunoregulatory T cells or by direct induction of T-cell anergy or deletion. Although the molecular processes underlying anergy have been extensively studied, little is known about the molecular basis for peripheral T-cell deletion. Here, we determined the gene expression signature of periph...

Journal: :The Journal of Experimental Medicine 1992
J M LaSalle P J Tolentino G J Freeman L M Nadler D A Hafler

Major histocompatibility complex class II-positive human T cell clones are nontraditional antigen-presenting cells (APCs) that are able to simultaneously present and respond to peptide or degraded antigen, but are unable to process intact protein. Although T cell presentation of peptide antigen resulted in a primary proliferative response, T cells that had been previously stimulated by T cells ...

2017
Satyajit Rath Marije Baas Alix Besançon Tania Goncalves Fabrice Valette Hideo Yagita Birgit Sawitzki Hans-Dieter Volk Emmanuelle Waeckel-Enée Benedita Rocha Lucienne Chatenoud Sylvaine You

CD8 T cell anergy is a critical mechanism of peripheral tolerance, poorly investigated in response to immunotherapy. Here, using a pancreatic islet allograft model and CD3 antibody therapy, we showed, by single cell gene profiling, that intragraft CD8 lymphocytes coexpressing granzyme B and perforin were selectively depleted through the Fas/FasL pathway. This step led to long-standing anergy of...

2015
Aline Sähr Sandra Förmer Dagmar Hildebrand Klaus Heeg

Bacterial superantigens (SAg) are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that SAgs cause activation and inactivation/anergy of T-cells was soon recognized. The structural and molecular events following SAg binding to antigen presenting cells (APCs) followed by crosslinking of T-cell receptors were characterized in detail. Activation, cytokine ...

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