نتایج جستجو برای: and ns5a proteins

تعداد نتایج: 16874701  

2016
Nari Kim Min-Jung Kim Pil Soo Sung Yong Chul Bae Eui-Cheol Shin Joo-Yeon Yoo

Hepatitis C virus (HCV) utilizes autophagy to promote its propagation. Here we show the autophagy-mediated suppression of HCV replication via the endoplasmic reticulum (ER) protein SCOTIN. SCOTIN overexpression inhibits HCV replication and infectious virion production in cells infected with cell culture-derived HCV. HCV nonstructural 5A (NS5A) protein, which is a critical factor for HCV RNA rep...

Journal: :Journal of virology 2014
Hyo-Young Chung Meigang Gu Eugen Buehler Margaret R MacDonald Charles M Rice

UNLABELLED Hepatitis C virus (HCV) is a widespread human pathogen causing liver cirrhosis and cancer. Similar to the case for other viruses, HCV depends on host and viral factors to complete its life cycle. We used proteomic and yeast two-hybrid approaches to elucidate host factors involved in HCV nonstructural protein NS5A function and found that MOBKL1B interacts with NS5A. Initial experiment...

Journal: :Molecular pharmacology 2006
Garret R Anderson Aliya Hasan Hao Yin Ishtiaq Qadri Linda C Quattrochi

Exposure to hepatitis C virus (HCV) can lead to the development of cirrhosis and hepatocellular carcinoma. To examine the effects of long-term HCV infection on hepatic cytochrome P450 1A1 (CYP1A1) expression and function, we used a human hepatoma cell line expressing the HCV subgenomic replicon (Huh.8) to evaluate CYP1A1 induction by the aryl hydrocarbon receptor (AhR) ligand, 2,3,7,8-tetrachlo...

Journal: :Antimicrobial agents and chemotherapy 2014
Mei Yu Betty Peng Katie Chan Ruoyu Gong Huiling Yang William Delaney Guofeng Cheng

Genotype 6 (GT6) hepatitis C virus (HCV) is prevalent in Southeast Asia and southern China, where it can constitute up to 50% of HCV infections. Despite this, no direct-acting antivirals are approved to treat GT6 HCV infection, and no cell culture systems have been described. In this study, we aimed to develop a GT6 HCV subgenomic replicon to facilitate the identification and development of new...

2017
Jing Guo Dan Chen Xiaoxiao Gao Xue Hu Yuan Zhou Chunchen Wu Yun Wang Jizheng Chen Rongjuan Pei Xinwen Chen

Hepatitis C virus (HCV) replication in cells is controlled by many host factors. In this report, we found that protein inhibitor of activated STAT2 (PIAS2), which is a small ubiquitin-like modifier (SUMO) E3 ligase, restricted HCV replication. During infection, HCV core, NS3 and NS5A protein expression, as well as the viral assembly and budding efficiency were enhanced when endogenous PIAS2 was...

Journal: :Journal of virology 2013
Michael Lauck Samuel D Sibley James Lara Michael A Purdy Yury Khudyakov David Hyeroba Alex Tumukunde Geoffrey Weny William M Switzer Colin A Chapman Austin L Hughes Thomas C Friedrich David H O'Connor Tony L Goldberg

GB virus B (GBV-B; family Flaviviridae, genus Hepacivirus) has been studied in New World primates as a model for human hepatitis C virus infection, but the distribution of GBV-B and its relatives in nature has remained obscure. Here, we report the discovery of a novel and highly divergent GBV-B-like virus in an Old World monkey, the black-and-white colobus (Colobus guereza), in Uganda. The new ...

2014
Jingjing Pei Mingqiu Zhao Zuodong Ye Hongchao Gou Jiaying Wang Lin Yi Xiaoying Dong Wenjun Liu Yongwen Luo Ming Liao Jinding Chen

Autophagy plays an important role in cellular responses to pathogens. However, the impact of the autophagy machinery on classical swine fever virus (CSFV) infection is not yet confirmed. In this study, we showed that CSFV infection significantly increases the number of autophagy-like vesicles in the cytoplasm of host cells at the ultrastructural level. We also found the formation of 2 ubiquitin...

Journal: :Antiviral research 2014
Eva Poveda David L Wyles Alvaro Mena José D Pedreira Angeles Castro-Iglesias Edward Cachay

Resistance to direct-acting antiviral (DAA) agents against hepatitis C virus (HCV) infection is driven by the selection of mutations at different positions in the NS3 protease, NS5B polymerase and NS5A proteins. With the exception of NS5B nucleos(t)ide inhibitors, most DAAs possess a low genetic barrier to resistance, with significant cross-resistance between compounds belonging to the same fam...

Journal: :Journal of virology 2001
J T Guo V V Bichko C Seeger

Chronic hepatitis C virus (HCV) infections can be cured only in a fraction of patients treated with alpha interferon (IFN-alpha) and ribavirin combination therapy. The mechanism of the IFN-alpha response against HCV is not understood, but evidence for a role for viral nonstructural protein 5A (NS5A) in IFN resistance has been provided. To elucidate the mechanism by which NS5A and possibly other...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید