نتایج جستجو برای: anaplastic lymphoma kinase

تعداد نتایج: 333698  

Journal: :Blood 2015
Jeffrey J Bednarski

9. Ogura M, Tobinai K, Hatake K, et al. Phase I / II study of brentuximab vedotin in Japanese patients with relapsed or refractory CD30-positive Hodgkin’s lymphoma or systemic anaplastic large-cell lymphoma. Cancer Sci. 2014;105(7):840-846. 10. Gotlib J, Berubé C, Growney JD, et al. Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation...

2017
Hyun-Nam Seo Jin-Ho Seo Cheol-Young Lee Jihye Song Jong-Hyun Kim Hyun-Woo Kim

Anaplastic large T-cell lymphoma (ALCL) encompasses different clinical entities that can be aggressive or localized. Scalp anaplastic lymphoma kinase (ALK)-negative ALCL is considered a localized lymphoma, and usually extends to the regional lymph nodes; intracranial invasion is rare. A 74-year-old woman was diagnosed with scalp ALK-negative ALCL, but did not exhibit invasion of the lymph nodes...

2015
Hee Kyung Kim Bo Hye Kim Sae Ahm Kim Jae Kyoung Shin Ji-Hyun Song Ah-Young Kwon Jung-Hyun Kim Eun-Kyung Kim Ji-Hyun Lee Gwaung-Il Kim Hye Cheol Jeong

Primary anaplastic large cell lymphoma (ALCL) of the lung is highly aggressive and quite rare. We report here a case of anaplastic lymphoma kinase-positive endobronchial ALCL, that was initially thought to be primary lung cancer. A 68-year-old woman presented with hemoptysis, dyspnea, and upper respiratory symptoms persisting since 1 month. The hemoptysis and and bronchial obstruction lead to r...

Journal: :Blood 2004
Irina Bonzheim Eva Geissinger Sabine Roth Andreas Zettl Alexander Marx Andreas Rosenwald Hans Konrad Müller-Hermelink Thomas Rüdiger

Anaplastic large cell lymphoma (ALCL) designates a heterogeneous group of CD30(+) (systemic or primary cutaneous) peripheral T-cell lymphomas (PTCLs). A subgroup of systemic ALCL is transformed by anaplastic lymphoma kinase (ALK). We compared 24 ALK(+), 15 ALK(-) systemic, and 7 cutaneous ALCLs with 29 nonanaplastic PTCLs in terms of T-cell receptor (TCR) rearrangements, expression of TCRs and ...

Journal: :International journal of clinical and experimental pathology 2014
Cai-Xia Wang Hai Wang Jie Li Heng-Hui Ma Bo Yu Shan-Shan Shi Xiao-Jun Zhou Qun-Li Shi

Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin lymphoma composed of CD30-positive cells and now recognized as three different entities: primary cutaneous ALCL, primary systemic anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL and primary ALK-negative (ALK-) ALCL. ALK+ ALCL is supposed to have a better prognosis than ALK- ALCL. It is rarely metastasized to other sites, es...

Journal: :Blood 2003
Pascale De Paepe Mathijs Baens Han van Krieken Bruno Verhasselt Michel Stul Annet Simons Bruce Poppe Geneviève Laureys Paul Brons Peter Vandenberghe Frank Speleman Marleen Praet Chris De Wolf-Peeters Peter Marynen Iwona Wlodarska

We present 3 cases of large B-cell lymphoma (LBCL) with a granular cytoplasmic staining for anaplastic lymphoma kinase (ALK). All of the cases showed striking similarities in morphology and immunohistochemical profile characterized by a massive monomorphic proliferation of CD20-/CD138+ plasmablast-like cells. In one of the cases, initially diagnosed as a null-type anaplastic large cell lymphoma...

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