The influence of oxygen and temperature on the inactivation of pyruvate,Pi dikinase and NADP-malate dehydrogenase was studied in Zea mays. 02 was required for inactivation of both pyruvate,Pi dikinase and NADP-malate dehydrogenase in the dark in vivo. The rate of inactivation under 2% 02 was only slightly lower than that at 21% 02. The in vitro inactivation of pyruvate,Pi dikinase, while depend...

Candida glabrata, an opportunistic fungal pathogen, adheres to mammalian epithelial cells; adherence is mediated primarily by the Epa1 adhesin. EPA1 is a member of a large gene family of ≈ 23 paralogues, which encode putative adhesins. In this study, we address how EPA1 transcription is regulated. Our data show that EPA1 expression is subject to two distinct negative regulatory mechanisms. EPA1...

p53 promotes apoptosis in response to death stimuli by transactivation of target genes and by transcription-independent mechanisms. We recently showed that wild-type p53 rapidly translocates to mitochondria in response to multiple death stimuli in cultured cells. Mitochondrial p53 physically interacts with antiapoptotic Bcl proteins, induces Bak oligomerization, permeabilizes mitochondrial memb...

This note is concerned with the problem of semi-globally stabilizing a linear system with an input delay and a constraint on the energy of its input. Under the condition of null controllability with vanishing energy, the parametric Lyapunov equation based L2 low gain feedback is adopted to solve the problem. The proposed approach is applied to the linearized model of the relative motion in the ...

The pole assignment method for non-delay multivariable systems has received a great deal of attention for designing feedback controllers to achieve desired objectives [1], [2]. Suh and Bien [3] have considered a root locus technique for linear systems with time-delay. Here is an attempt to present a pole assignment method for multi-input systems with input delay. The single-input system with de...

Objective(s) Doxorubicin (DOX), a widely used chemotherapeutic agent can give rise to serve cardiotoxicity by inducing apoptosis. Curcumin, the active compound of the rhizome of Curcuma longa L. has anti-inflammatory, antioxidant and anti-proliferative activities. Curcumin has been identified to increase cytotoxicity in several cancer cell lines in combination with DOX, but there is no study a...

The robust stability analysis of asynchronous and uncertain sampled-data systems with constant incremental input delay is addressed in the looped-functional framework. These functionals have been shown to be suitable for the analysis of impulsive systems as they allow one to express discrete-time stability conditions in an affine way, enabling then the consideration of uncertain and time-varyin...

This work presents a new discrete-time adaptive-predictive control algorithm for a system with force disturbance and input delay. This scenario is representative of a mechatronic device for percutaneous intervention with pneumatic actuation and long supply lines which is controlled remotely in the presence of an unknown external force resulting from needle-tissue interaction or gravity. The ult...

Phagocytic cells generate superoxide (02 ) as a part of the respiratory burst of phagocytosis. We studied human granulocyte #{176}2 production in vitro in response to phorbol myristate acetate, a soluble fatty acid ester that stimulates 02 generation. The properties of this compound permit the adaptation of a continuous assay of 0 production to the study of the activity and activation (i.e., th...

The maximum germination rate of Bacillus megaterium QM B1551 spores in glucose increased, and the lag before its attainment decreased, with increasing germination temperature. The activation energy for germination (mu = approximately 20 kcal/mole), based on rate or on lag, was consistent with an enzymatic mechanism.