Actinic keratosis is a common disease in humans, which also affects dogs. Lesions occur in chronically sun exposed areas, such as flank, ventral and lateral abdomen. It has been reported that actinic keratosis is a pre-neoplastic disease which may evolve into squamous cell carcinoma (SCC), which is one of the most frequent malignant neoplasm in dogs. The aim of this research was to investigate ...

Imiquimod 5% cream (Aldara, 3M Pharmaceuticals) is a topical immunomodulator approved for the treatment of genital warts, actinic keratoses, and superficial basal cell carcinoma, although it is also used off-label in clinical practice for other dermatologic conditions. Although local side effects are most frequent, it can also produce systemic side effects. We describe the case of a patient who...

Erosive pustular dermatosis of the scalp is a rare inflammatory skin disease that mainly affects older patients and is characterized by the presence of sterile pustules and scabs. Recently, several authors have reported the usefulness of photodynamic therapy in the treatment of this condition. We present the case of a 79-year-old man with skin phototype III and actinic keratosis of the face and...

OBJECTIVE To review the epidemiology, etiology, diagnosis, management, and prognosis of the most common, potentially lethal, lip lesions: leukoplakia, actinic cheilitis, and squamous cell carcinoma (SCC). QUALITY OF EVIDENCE MEDLINE: was searched from 1966 to 2002 for English-language articles on prevalence of lip lesions. No articles for a family physician audience were found. MEDLINE was sear...

Actinic cheilitis is a potentially malignant lip lesion caused by excessive and prolonged exposure to ultraviolet radiation, which can lead to histomorphological alterations indicative of abnormal cell differentiation. In this pathology, varying degrees of epithelial dysplasia may be found. There are few published studies regarding the p53 and MDM2 proteins in actinic cheilitis. Fifty-eight cas...