Doxorubicin is a genotoxic chemotherapy agent used in treatment of a wide variety of cancers. Significant clinical side effects, including cardiac toxicity and myelosuppression, severely limit the therapeutic index of this commonly used agent and methods which improve doxorubicin efficacy could benefit many patients. Because doxorubicin cytotoxicity is cell cycle specific, the cell cycle is a r...

Dis3 is a highly conserved exoribonuclease which degrades RNAs in the 3'-5' direction. Mutations in Dis3 are associated with a number of human cancers including multiple myeloma and acute myeloid leukemia. In this work, we have assessed the effect of a Dis3 knockdown on Drosophila imaginal disc development and on expression of mature microRNAs. We find that Dis3 knockdown severely disrupts the ...

Coronavirus disease 2019 pandemic impacted across the globe disrupting all sectors including higher education universities. Nursing institutions faced various challenges due to restrictions, of which abrupt shift implementing curriculum online mode posed a major challenge both teachers and students. To assess nursing students' perception pedagogy in remote teaching-learning, this cross-s...

The referendum on yesterday’s ballot w h ich recommended the adoption o f a bilateral freeze on nuclear weapons was passed overwhelm ingly by the student body. The final ta lly showed those favor­ ing the referendum w inn ing by a margin o f 2770, o r 76.9 percent, to 832, o r 231 percent. 53 percent o f the student body voted in the elec­ tion. people were not really aware o f the issue.” The ...

A fter four years of hardly keeping up with inflation, Indiana cropland values jumped around 10% in the year ending in June 1994 according to the Purdue land values survey. The USDA reported a 7.8% increase for the year ending January 1. Likely causes of strength in the land market include low interest rates (affecting both borrowers and equity investors), generally good yields in Indiana in 19...

3 4 Maria Knikou 1, , Luke Dixon , Danielle Santora , and Mohamed M. Ibrahim 2 5 6 7 The Graduate Center and Department of Physical Therapy, City University of New York, NY 8 10016 9 10 11 *Correspondence to: 12 Maria Knikou, PhD 13 Graduate Center / City University of New York 14 2800 Victory Boulevard, 5N-207 15 Staten Island, NY 10314 16 Phone: 718-982-3316 17 Fax: 718-982-2984 18 E-mail: Ma...