Introduction Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a newly described autoinflammatory disease, which had been recently reported in 9 patients. It is characterized by onset during the first year of life of recurrent fevers, purpuric skin lesions, arthralgia, progressive lipodystrophy, hypochromic or normocytic anemia, delayed ph...

Keith Mercer. Rough Justice: Policing, Crime, and the Origins of Newfoundland Constabulary, 1729–1871. St. John’s: Flanker Press, 2021. ISBN 978-1-77457-016-6. An article from journal Labrador Studies (Volume 36, Number 2, 2021, pp. 171-344), on Érudit.

We report new direct measurements of the Z-lepton coupling asymmetry parameters Ae, A and A , with polarized Z 's collected by the SLD detector at the SLAC Linear Collider. The parameters are extracted from the measurement of the left-right-forward-backward asymmetries for each lepton species. The 1996, 1997 and 1998 SLD runs are included in this analysis and combined with published data from t...

The role of clopidogrel in disruption of platelet aggregation is well known. The variability in clopidogrel response is a well-documented phenomenon and has been widely addressed through pharmacogenomics. CYP2C19 has been considered as genetic predictor of clopidogrel response. Owing to the inter-individual variations, CPIC (Clinical Pharmacogenetics Implementation Consortium) had issued guidel...

Introduction Blau syndrome is an autosomal dominant monogenic granulomatous disease associated with gain of function mutations at or near the NACHT domain of NOD2; it is the only form of granulomatous arthritis with a known gene mutation. Although its phenotype has been amply described as a triad of arthritis, uveitis and dermatitis in case series and retrospective cohorts, prospective studies ...