AIM To investigate the protective effect of medical ozone (O(3)) combined with Traditional Chinese Medicine (TCM) Yigan Fuzheng Paidu Capsules (YC) against carbon tetrachloride (CCl(4))-induced hepatic injury in dogs. METHODS Thirty healthy dogs were divided randomly into five groups (n = 6 in each group), namely control, oleanolic acid tablet (OAT), O(3), YC and O(3) + YC, given either no pa...

Our previous study demonstrated that 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) might activate the soluble guanylate cyclase (sGC)/cGMP/protein kinase G (PKG) pathway to induce cyclooxygenase-2 (COX-2) expression in human pulmonary epithelial cells (A549). In this study, we further investigated the role of Raf-1 in YC-1-induced nuclear factor-kappaB (NF-kappaB) activation and COX-2 e...

The definition of the train loading plan is one of the decisional aspects to be dealt with in a container terminal [1]. In the literature, few research studies have been devoted to the train load planning problem; among them, in [2] three different integer linear programming formulations are proposed in which the real weight restrictions related to wagons configurations are considered, as in th...

Due to its high capital investment, operating and maintenance cost, a port should be managed as efficiently as possible. Learning from the best practices ports operating under similar conditions is a very useful strategy for maintaining competiveness. Under such a competitive environment, port performance measurement is not only a powerful management tool for port operations, but also constitut...

Oral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic agent for oral cancer therapy. However, the development of drug resistance and severe side effects cause tremendous problems clinically. In this study, we investigated the pharmacologic mechanisms of YC-1 on cisplatin-resistant human oral cancer cell line, CAR. Our results indicated that YC-1 induced a c...

DENEV, S. A., Tz. PEEVA, P. RADULOVA, P. STANCHEVA, G. STAYKOVA, G. BEEV, P. TODOROVA and S. TCHOBANOVA, 2007. Yeast cultures in ruminant nutrition. Bulg. J. Agric. Sci. 13: 357-374 Interest in the use of fungal direct-fed microbials in ruminant nutrition is considerable. The ban of antibiotic growth promoters in feed for production of animal foods has increased interest in evaluating the effec...

From 1990-2001, we made 188 successful captures of 166 different greater sandhill cranes (Grus canadensis tabida) through experimental use of alpha-chloralose (AC). Most captures took place during September (72.3%; n = 136), followed by August (14.9%; n = 28), and October (12.8%; n = 24). Territorial pairs were captured more successfully than family groups. Overall morbidity (6.4%) and mortalit...

The principal spring staging areas of the midcontinent population of sandhill cranes (Grus canadensis) are along the Platte and North Platte rivers in south-central Nebraska. Most of these lands are privately owned and managed for corn and cattle production. Diurnal habitat use by radio-tagged cranes was primarily in cropland (55%), native grassland (28%), and tame hayland (15%). Ninety-nine pe...

Vessel discharge and load jobs in a container terminal can be divided into sequences, one for each assigned quay crane (QC). A QC sequence lists containers in their desired handling order. The common practice for operators is to make do with just this sequence, without generating a job schedule (i.e. desired start-times of handling each container). Operators who need job schedules generate crud...

Background: YC-1 (3-(5'-hydroxymethyl-2'furyl)-1-benzyl-indazole) is an allosteric activator of soluble guanylyl cyclase (sGC) and a vasodilator. This study describes a paradox action of YC-1 in isolated vessels of coronary artery disease (CAD) patients which appears to trigger an endothelium-dependent vasoconstrictor pathway present in vessels with endothelial dysfunction. Methods: Effects of ...