Palm tocotrienol-rich fraction (TRF), an extract from palm oil containing both tocotrienol and tocopherol, is known for its antioxidant effect. The present study investigated the effect of palm TRF on the stomach using a water immersion restraint stress (WRS) model. Fortytwo male Sprague-Dawley rats were divided into three groups and were administered 60 mg/kg/d of palm TRF, α-tocopherol or veh...

The plasma or serum levels of various enzymes and components are known to increase in rats with water-immersion restraint stress (WIRS). We examined whether oxidative stress is involved in increases in the serum levels of various enzymes and components in rats with WIRS. Rats were exposed to WIRS for 6 h after oral administration of vitamin E (VE) (50 or 250 mg/kg). Rats with WIRS had increased...

The present study was conducted to clarify the protective effect of Brazilian propolis ethanol extract (BPEE) against stress-induced gastric mucosal lesions in rats. The protective effect of BPEE against gastric mucosal lesions in male Wistar rats exposed to water-immersion restraint stress (WIRS) for 6 h was compared between its repeated preadministration (50 mg/kg/day, 7 days) and its single ...

Objective(s): Based on our previous studies about nano-ZnO effects on physiological behaviors, in this study we have investigated the effects of anxiolytic doses of nano-ZnO on electrocardiogram (ECG) sings changes in the restraint and non-restraint ovariectomized (OVX) female rats. Methods: Animals (160-180 g) were divided into: control (non-OVX + saline) and OVX groups that received: s...

Central corticotropin-releasing factor (CRF) plays an important role in mediating restraint stress-induced delayed gastric emptying. However, it is unclear how restraint stress modulates gastric motility to delay gastric emptying. Inasmuch as solid gastric emptying is regulated via antropyloric coordination, we hypothesized that restraint stress impairs antropyloric coordination, resulting in d...