A 36-year-old transgender man (assigned female at birth) on exogenous testosterone therapy was found to have stage IIA ovarian endometrioid carcinoma, and underwent adjuvant chemotherapy. Diffuse androgen receptor expression in the tumor initiated a multidisciplinary discussion regarding safety of continuing as gender-affirming hormone therapy.

Introduction: Modern radiotherapy (RT) techniques allow a highly precise deposition of the radiation dose in tumor. So, high conformal tumor doses can be reached while sparing critical organs at risk. Materials and Methods: This study was conducted in three phases. In the first phase; Fourteen patients with primary or recurrent prostate cancer receive Gallium-...

   In recent years, Hyperthermia has been used as an emerging technique for cancer treatment, especially for localized tumors. One of the promising cancer treatment approaches is magnetic nanoparticle (MNPs) Hyperthermia. In this theoretical work, the temperature distribution of a common tumor over the different sizes of Fe3O4 magnetic nanoparticles, namely 25, 50, 100, and 200 nm, was stud...

Osteosarcoma is a malignant bone tumor that usually affects children and adolescents. Early detection of osteosarcoma tumors increases the likelihood successful therapy. Manual identification requires highly skilled doctors. In this study, we attempt to create model automatically diagnose into three categories; non-tumor, viable-tumor, tumor. The suggested methodology can help medical professio...

Blood–Brain Barrier Therapy The blood–brain barrier (BBB) is a bottleneck in the treatment of brain tumors. In article number 2203678, Liang Wang, Yinyan Lin Feng, and co-workers summarize current approaches to overcome BBB, such as use “Trojan horse” molecular modifications for deception, describe variety micro-nanocarriers targeted tumor therapy.

background: the herpes simplex virus (hsv) ul41 gene product, virion host shutoff (vhs) protein, mediates the rapid degradation of both viral and cellular mrna. this ability suggests that vhs protein can be used as a suicide gene in cancer gene therapy applications. the recent reports have shown that the degradation of cellular mrna during herpes simplex infection is selective. rna containing a...

Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with poor response to conventional immune checkpoint inhibitors. Early data by our group suggests CD4 T cell depletion abrogates novel combination therapy that transiently curative in murine model of PDA. Given the importance cells PDA control, we now seek describe dynamics at an antigen-specific resolution. To this end, dev...

Cancer Immunotherapy In article number 2205044, Baorui Liu, Rutian Li, and co-workers constructed gelatinase-responsive NanoSwitch to control the activation process of CAR-T cells, leading on-site cells at tumor region in a sustainable way. This platform has promising potential prevent main obstacles therapy for solid tumors including cytokine-release syndrome on-target/off-tumor toxicity.

In article number 2001212 by Huile Gao, Xianchun Chen, and co-workers, recent progress of self-propelled micro/nanomotors for tumor drug delivery is reviewed. The force facilitates with autonomous movement, therefore exhibit potential enhanced efficiency in each step delivery, which includes circulation the blood, targeting, deep penetration, cellular internalization, release. combination thera...

Cancer is a mutagenic disorder which causes uncontrollable growth of cells in the body. This uncontrolled further produces tumor. action stimulates immune system can prevent or promote tumor growth. Novel strategies for treatment cancer are also to target this system. Many conventional treatments restricted particular organ So, these therapies no more use. second most fatal worldwide. Therefore...