BACKGROUND Imatinib, a tyrosine kinase inhibitor currently approved for treatment of several malignancies, has been shown to be a substrate for multiple efflux-transporter proteins, including ABCB1 (P-glycoprotein) and ABCG2 (BCRP). The effect of inhibiting these transporters on tissue exposure to imatinib remains unclear. OBJECTIVE To assess the role of these transporters on drug disposition...

Urine concentration is regulated by vasopressin. Congenital nephrogenic diabetes insipidus (NDI) is caused by vasopressin type 2 receptor (V2R) mutations. We studied whether metformin could improve urine concentration in rodent models of congenital NDI by stimulating AMPK. To block the V2R in rats, tolvaptan (10 mg/kg/d) was given by oral gavage with or without metformin (800 mg/ kg/d). Control...

Renal fibrosis plays an important role in the onset and progression of chronic kidney diseases (CKD). Although several mechanisms underlying renal fibrosis and candidate drugs for its treatment have been identified, the effect of iron chelator on renal fibrosis remains unclear. In the present study, we examined the effect of an iron chelator, deferoxamine (DFO), on renal fibrosis in mice with s...

In November of 2003 a rollout test was performed to gain a better understanding of the dynamic environment for the Space Shuttle during transportation from the Vehicle Assembly Building to the launch pad. This was part of a study evaluating the methodology for including the rollout dynamic loads in the Space Shuttle fatigue life predictions. The rollout test was conducted with a partial stack c...

background: injuries and accidents are one of the main problems in the present century. the purpose of this study was the identification and analysis of the characteristics of pre-hospital emergency motor vehicle accidents (mva) in rafsanjan, iran, in 2014. materials and methods: this cross-sectional descriptive study was performed on all patients recorded by pre-hospital emergency during a per...

In this study, stability control of a three-wheeled vehicle with two wheels on the front axle, a three-wheeled vehicle with two wheels on the rear axle, and a standard four-wheeled vehicle are compared. For vehicle dynamics control systems, the direct yaw moment control is considered as a suitable way of controlling the lateral motion of a vehicle during a severe driving maneuver. In accorda...

ZIP (Zinc-regulated transporter, Iron-regulated transporter-like Protein, ZIP) plays an important role in uptake or transport Zn Fe plants. So studying ZIPs plant can help to elucidate the molecular mechanism for and transportation. Herein, we have cloned a novel transporter gene NoZIP3 from Nasturtium officinale root using rapid-amplification of cDNA ends (RACE) method, evaluated its function ...

In the present study, the aim is to optimize full and half toroidal continuously variable transmission (CVT) in order to minimize the vehicle fuel consumption (FC) in ECE driving cycle. First, the model of both CVTs’ efficiency is presented. The control strategy of CVTs speed ratio based on minimizing the vehicle FC is introduced, and the algorithm of calculating the vehicle FC is shown. Afterw...

In distribution networks, failure to smooth the load curve leads to voltage drop and power quality loss. In this regard, electric vehicle batteries can be used to smooth the load curve. However, to persuade vehicle owners to share their vehicle batteries, we must also consider the owners' profits. A challenging problem is that existing methods do not take into account the vehicle owner demands ...