Mucosa-adhesive gels can be used as a useful mean of delivering drugs to or via mucosal membranes, and in particular buccal mucosa. Carbomers are among the best mucosa-adhesive materials known. The aim of this study was to compare the results obtained from the mucosa-adhesive strength of aqueous gels containing Carbomers, either alone or in combination, to the data obtained from assessing the d...

Mucosa-adhesive gels can be used as a useful mean of delivering drugs to or via mucosal membranes, and in particular buccal mucosa. Carbomers are among the best mucosa-adhesive materials known. The aim of this study was to compare the results obtained from the mucosa-adhesive strength of aqueous gels containing Carbomers, either alone or in combination, to the data obtained from assessing the d...

aim : the aim of this study is to design multi-walled carbon nanotubes (mwcnts) loaded with paclitaxel (ptx) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer. the sidewall surfaces of pristine mwcnts are highly hydrophobic. a major goal in carbon nanotube chemistry has been functionalization for aqueous solubility, and exploiting nano-tubes as macromolecules ...

      Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine wh...

OBJECTIVE Betahistine dihydrochloride (BH.2HCl), an anti-vertigo histamine analog used in the treatment of Ménière's disease, undergoes extensive first-pass metabolism and suffers from short biological half-life. The aim of the present work was to develop and estimate controlled release mucoadhesive buccal tablets of BH.2HCl with a unidirectional drug flow to overcome this encumbrance. METHOD...

the present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. sba-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (mpts). the parent and thiol-functionalized sba-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). the charac...

a great challenge in using natural polysaccharide as drug delivery system is their fast drug release. the purpose of the present study was to prepare and evaluate chitosan oligosaccharide (cho)-de-estrifiedtragacanth (det) core-shell nanoparticles for controled release of water soluble drugs. cho-det nanoparticles were prepared by microemulsion method and characterized by ft-ir spectroscopy. si...

Nowadays, polymer nanofibers have gained attention due to remarkable characteristics such as high porosity and large surface area to volume ratio. Among their fabrication methods, electrospinning technique has been attracted as a simple and reproducible approach. It is a versatile, simple and cost-effective technique for the production of continuous nanofibers with acceptable characteristics su...