Drug-like and lead-like hits derived from HTS campaigns provide good starting points for lead optimization. However, too strong emphasis on potency as hit-selection parameter might hamper the success of such projects. A detailed absorption, distribution, metabolism, excretion and toxicology (ADME-Tox) profiling is needed to help identify hits with a minimum number of (known) liabilities. This i...

In cattle, phenotypic expression of reproductive traits occurs late in life. The identification of causal mutations in genes affecting reproduction permits the inclusion of these SNPs in customized DNA chips to increase accuracy. Therefore, the aim of this study was to detect causal mutations in the TOX and NCOA2 genes previously identified by genome-wide association studies of zebu cattle. DNA...

T lymphocytes accumulate in inflamed tissues of patients with chronic inflammatory diseases (CIDs) and express pro-inflammatory cytokines upon re-stimulation vitro. Further, a significant genetic linkage to MHC genes suggests that play an important role the pathogenesis CIDs including juvenile idiopathic arthritis (JIA). However, functions established disease remain elusive. Here we dissect tra...

Marine and coastal ecosystems are the ultimate sink of many contaminants from anthropogenic activities, such as trace elements. Although several ecotoxicological tests available using autotrophic organisms, none focus on marine plants. Juncus acutus has already showed that it is a good candidate for studies, providing set contamination biomarkers. The present work evaluates application pulse am...

In these last years several works have been devoted to study the radiation effect in CMOS components with ultrathin gate oxide, showing that different types of leakage current can be produced by high-energy ionizing radiation. Radiation Induced Leakage Current (RILC) [1-2], Radiation Soft Breakdown (RSB) [3-5], and Single Event Gate Rupture (SEGR) [6] represent the most important degradation ph...