In differential diagnosis of pleural effusions, cytology is the most sensitive method. Since cytology findings are positive in half of such fluids, combined use of reliable tumor marker and cytology is a logical approach. Sialic acid and other tumor markers can be reliable substances associated with neoplasia. The present study measured sialic acid levels in pleural effusion and serum samples o...

Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of vertebrates and so-called "higher" invertebrates, and on certain bacteria that interact with vertebrates. This overview surveys examples of biological roles of sialic acids in immunity, with emphasis on an evolutionary perspective. Given the breadth of the subject, the treatment of individual topics is...

Introduction The sialic acids comprise a diverse family of nine-carbon keto-sugars, the majority of which are structural derivatives of neuraminic acid (Fig. 1). Neuraminic acid has an amino moiety at the C-5 position, and carboxylate at C-2 which confers negative charge at physiological pH. Whereas unsubstituted neuraminic acid is not known to exist in nature, over 40 substituted variations (c...

Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has been identified as a novel potential target for cancer immunotherapy. Here, we explored the role of Siglec-15 in human hepatoma cells. In this study, found that expression is substantially upregulated liver tissues comparison with nontumor tissues. Functionally, vitro experiments show promotes migration Furthermore, data demonstr...

N-acetylneuraminic acid (Neu5Ac) represents the most common terminal carbohydrate residue in many mammalian glycoconjugates and is directly involved in a number of different physiological as well as pathological cellular processes. Endogenous sialic acids derive from the biosynthetic precursor molecule N-acetyl-D-mannosamine (ManNAc). Interestingly, N-acyl-analogues of D-mannosamine (ManN) can ...

Viruses of the Adenoviridae family are widespread in society and are associated with a wide variety of clinical symptoms in humans, including respiratory, gastrointestinal, and ocular diseases. Epidemic keratoconjunctivitis (EKC) is a severe ocular infection and is caused by the highly contagious adenoviruses Ad8, Ad19, and Ad37. Besides keratitis and conjunctivitis, other common symptoms of EK...

Sialic acid, oral glucose and plasma lipids were determined in 70 control subjects (age range 20-60) and 150 individuals of (age range 20-60) who were offspring of one type 2 diabetic parent. The number of first degree relatives who had impaired glucose tolerance were 50. The total sialic acid concentration was significantly higher (p<0.05) in the first degree relatives when compared to the con...