To increase the update rates of topographical databases, research is performed to automatically detect changes using airborne laser scanning data. After the determination of the bare-Earth points, the remaining points have been classified as either points on buildings or points on vegetation. Additional usage was made of registered colour imagery taken during the laser scanning survey. The resu...

The apparently effortless identification of speech is one of the human auditory cortex' finest and least understood functions. This is partly due to difficulties to tease apart effects of acoustic and phonetic attributes of speech sounds. Here we present evidence from magnetic source imaging that the auditory cortex represents speech sounds (such as [g] and [t]) in a topographically orderly fas...

Because of the decline of physical abilities of the elderly, their mobility is more vulnerable to topographical factors than younger population groups. However, topographical factors have been neglected in studies on travel behavior, and elderly people’s heterogeneous responses to topographical factors remain unknown. To fill this research gap, this study focuses on a hilly neighborhood called ...

We used a recently developed test of spatial memory--the Four Mountains Test--to investigate the core cognitive processes underpinning topographical disorientation in patients with amnestic mild cognitive impairment (a-MCI) and mild Alzheimer's disease (AD). Performance of these clinical groups was compared with age-matched controls, patients with frontotemporal lobar degeneration (FTLD), and p...

Resveratrol is a natural compound found in red wine that has been suggested to exert its potential health benefit through the activation of SIRT1, a crucial member of the mammalian NAD+-dependent deacetylases. SIRT1 has emerged as an attractive therapeutic target for many aging related diseases, however, how its activity can only be activated toward some specific substrates by resveratrol has b...

The human skin is an organ with a surface area of 1.5-2 m(2) that provides our interface with the environment. The molecular composition of this organ is derived from host cells, microbiota, and external molecules. The chemical makeup of the skin surface is largely undefined. Here we advance the technologies needed to explore the topographical distribution of skin molecules, using 3D mapping of...

Controlling the domain size and degree of crystallization in organic films is highly important for electronic applications such as organic photovoltaics, but suitable nanoscale mapping is very difficult. Here we apply infrared-spectroscopic nano-imaging to directly determine the local crystallinity of organic thin films with 20-nm resolution. We find that state-of-the-art pentacene films (grown...