1. Skin irritation refers to the production of reversible damage to the skin following the application of a test chemical for up to 4 hours [as defined by the United Nations (UN) Globally Harmonized System of Classification and Labelling of Chemicals (GHS)](1). This Test Guideline (TG) provides an in vitro procedure that may be used for the hazard identification of irritant chemicals (substance...

This paper introduces Improcess, a novel cross-disciplinary collaborative project focussed on the design and development of tools to structure the communication between performer and musical process. We describe a 3-tiered architecture centering around the notion of a Common Music Runtime, a shared platform on top of which inter-operating client interfaces may be combined to form new musical in...

Direct interfacing of nanosensors onto biomaterials could impact health quality monitoring and adaptive threat detection. Graphene is capable of highly sensitive analyte detection due to its nanoscale nature. Here we show that graphene can be printed onto water-soluble silk. This in turn permits intimate biotransfer of graphene nanosensors onto biomaterials, including tooth enamel. The result i...

Quality of the school system is an important consideration for parents when homeschooling children. The research aims to measure and assess success strategy improve quality basic education institutions at SD/MI level. focus analysis indicators measuring assessing as well level in organization effort institutions. This uses a qualitative approach with method literature study. data sources materi...

Chemical libraries paired with phenotypic screens can now readily identify compounds with therapeutic potential. A central limitation to exploiting these compounds, however, has been in identifying their relevant cellular targets. Here, we present a two-tiered CRISPR-mediated chemical-genetic strategy for target identification: combined genome-wide knockdown and overexpression screening as well...

An empirically based cognitive model of real-world decision making was implemented in Shruti, a system capable of rapid, parallel relational reasoning. The system effectively simulates a two-tiered strategy associated with proficient decisions makers: Recognitional or reflexive activation of expectations and associated responses, accompanied by an optional, recursive process of critiquing and c...