The phenomenon of "acute tolerance" to thiopentone was re-examined in 82 subjects with induction doses of 2-15mg kg-1. There was a strong positive correlation between the venous plasma thiopentone concentrations on recovery from anesthesia and the induction dose, expressed as either mg kg-1 or mg m-2. Recovery time was proportionately shorter with larger doses, being directly related to log10 o...

background: electroconvulsive therapy (ect) is usually given to people with severe depression which has not responded to other forms of treatment such as anti-depressants. ect may be accompanied by potentially significant medical complications including prolonged seizures, prolonged apnea, or cardiac or pulmonary complications. modification of ect with brief anesthesia and muscle relaxants shou...

Several studies suggest that anesthetics modulate the immune response. The aim of this study was to investigate the effect of halothane and thiopental on the lung inflammatory response. Rats submitted or not to intratracheal (IT) instillation of lipopolysaccharides (LPS) were anesthetized with either halothane (0. 5, 1, or 1.5%) or thiopental (60 mg. kg(-1)) and mechanically ventilated for 4 h....

OBJECTIVE To compare the effects of propofol and thiopental on haemodynamics, awareness and newborns in pregnant women undergoing elective caesarean section. METHODS Seventy pregnant women were assigned into two equal groups. For anaesthesia induction, 2 mg kg(-1) propofol (Group P) and 5 mg kg(-1) thiopental (Group T) were administered. Maternal haemodynamic parameters and bispectral index (...

BACKGROUND AND OBJECTIVE The combination of alfentanil-propofol or remifentanil-propofol provides adequate conditions for tracheal intubation without neuromuscular blocking drugs in most patients, but hypottension can occur during induction of anesthesia with propofol. We compared clinically acceptable intubating conditions and cardiovascular responses to induction and endotracheal intubation i...

Background: Thiopental has been used as a pharmacological cerebral protection strategy during carotid endarterectomy surgeries. However, the optimal dosage required to induce burst suppression on electroencephalogram (EEG) remains unknown. This retrospective study aimed determine of thiopental non-shunt endarterectomy. Methods: The...

The methanolic leaf extract of Thuja occidentalis was evaluated for possible sedative activities in mice. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and elevated-plus maze (EPM) tests at 200mg/kg and 400 mg/kg.  The extract decreased the locomotor activity of mice in hole cross, open field and EPM test and showed the remarka...