Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. The bioavailability of geniposide by nasal route is greater than that by oral administration. However, mucociliary clearance is a rate-limiting factor for nasal route administration...

this articles is comprised of two parts: a) an experimental investigation on the behavior of an acrylic gel under dc electric field and b) a physico - mathematical description.a) gel rods made of poly [acrylamide-co-bisacrylamide] were partially hydrolyzed to different extents at ph 12 by teteramethylethylene diamine. equlibrium properties of the resulting gels rods (water content, number of ca...

conclusions our method provided good results and performing evacuation under the guide of bedside ultrasonography is recommended. results we treated 173 patients, including 164 females (94.8%), with the mean (sd) age of 43.75 (10.62) years. according to vas, 95.4% of patients reported complete satisfaction while 2 (1.2%) were unsatisfied with the results. patients reported no complication of th...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

mucosa-adhesive gels can be used as a useful mean of delivering drugs to or via mucosal membranes, and in particular buccal mucosa. carbomers are among the best mucosa-adhesive materials known. the aim of this study was to compare the results obtained from the mucosa-adhesive strength of aqueous gels containing carbomers, either alone or in combination, to the data obtained from assessing the d...

background and objectives: making stacking gels for polyacrylamide gels in the laboratory by conventional methods is laborious and time consuming. considering the role of temperature in polyacrylamide gels with respect to electrical resistance and viscosity, we assumed that decreasing the temperature would cause an increase in electrical resistance and viscosity.  ultimately, a downward tempera...

Novel structural transitions of solvent-free oligomer-grafted nanoparticles are investigated by using molecular dynamics simulations of a coarse-grained bead-spring model. Variations in core size and grafting density lead to self-assembly of the nanoparticles into a variety of distinct structures. At the boundaries between different structures, the nanoparticle systems undergo thermoreversible ...