Navigation of nanoparticles to target sites blood flow disturbance markedly upgrades the diagnostic paradigm in vascular medicine. The theranostic treatment pre-stenotic vessels can prevent irreversible occlusion process effectively. Here, these nanotheranostic functions are established by displaying CDK9(cyclin-dependent kinase 9)-targeting peptide (P.) onto nanovesicles (NV) and liposomes usi...

Protein–protein interaction (PPI) is one of the key regulatory features driving biomolecular processes and hence targeted for designing therapeutics against diseases. Small peptides are a new emerging class owing to their high specificity low toxicity. For achieving efficient targeting PPI, amino acid side chains often stapled together, resulting in rigidification these peptides. Exploring scop...

Antigen-induced peripheral tolerance is potentially one of the most efficient and specific therapeutic approaches for autoimmune diseases. Although highly effective in animal models, antigen-based strategies have not yet been translated into practicable human therapy, and several clinical trials using a single antigen or peptidic-epitope in multiple sclerosis (MS) yielded disappointing results....

PNAs conjugated to carrier peptides have been employed for the targeting of miRNA precursor, with the aim to develop molecules able to interfere in the pre-miRNA processing. The capability of the molecules to bind pre-miRNA has been tested in vitro by fluorescence assayes on Thiazole Orange labeled molecules and in vivo, in K562 cells, evaluating the amount of miRNA produced after treatment of ...

Hypervalent iodine compounds are powerful reagents for the development of novel transformations. As they exhibit low toxicity, high functional group tolerance, and stability in biocompatible media, have been used functionalization biomolecules. Herein, we report recent advances up to June 2021 peptide protein modification using hypervalent reagents. Their use as transfer or oxidizing is discuss...

In the present study, we report the design and synthesis of peptide-based-multi-walled carbon nanotubes (MWCNTs) to target mitochondria. Targeting these intracellular organelles might open the way to develop alternative systems to address diseases related to genetic mutations in mitochondrial (mt)-DNA, by delivering therapeutic oligonucleotides. The first step towards mitochondrial delivery of ...

A versatile synthetic platform for the efficient immobilization of PNAs on magnetic iron oxides, providing magnetic nanosensors for selective DNA recognition, is presented.

Purpose Transforming growth factor β (TGFβ) is upregulated in many types of tumors and plays important roles tumor microenvironment construction, immune escape, invasion, metastasis. The therapeutic effect antibodies nuclide-conjugated drugs targeting TGFβ has not been ideal. Targeting with small-molecule or peptide carriers labeled diagnostic/therapeutic nuclides a new development direction. T...

RNA interference has been used to dissect the importance of individual gene products in various human disease processes, including cancer. Small-interfering RNA, or siRNA, is one of the tools utilized in this regard, but specially-designed delivery agents are required to allow the siRNA to gain optimal access to the cell interior. Our laboratory has utilized two different siRNA-binding delivery...

Peritoneal carcinomatosis results from dissemination of solid tumors in the peritoneal cavity, and is a common site of metastasis in patients with carcinomas of gastrointestinal or gynecological origin. Peritoneal carcinomatosis treatment is challenging as poorly vascularized, disseminated peritoneal micro-tumors are shielded from systemic anticancer drugs and drive tumor regrowth. Here, we des...