نتایج جستجو برای: subcutaneous human adipocyte

تعداد نتایج: 1676266  

2011
Pernille Keller Valentina Gburcik Natasa Petrovic Iain J Gallagher Jan Nedergaard Barbara Cannon James A Timmons

BACKGROUND Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in adipogenesis is less well studied. We thus set out to investigate whether miRNAs would be actively modulated during adipogenesis...

Journal: :American journal of physiology. Endocrinology and metabolism 2004
Jussi Sutinen Katja Kannisto Elena Korsheninnikova Rachel M Fisher Ewa Ehrenborg Tuulikki Nyman Antti Virkamäki Tohru Funahashi Yuji Matsuzawa Hubert Vidal Anders Hamsten Hannele Yki-Järvinen

Highly active antiretroviral therapy (HAART) has improved the prognosis of human immunodeficiency virus (HIV)-infected patients but is associated with severe adverse events, such as lipodystrophy and insulin resistance. Rosiglitazone did not increase subcutaneous fat in patients with HAART-associated lipodystrophy (HAL) in a randomized, double-blind, placebo-controlled trial, although it attenu...

2015
Yanbei Zhu Rongze Yang John McLenithan Daozhan Yu Hong Wang Yaping Wang Devinder Singh John Olson Carole Sztalryd Dalong Zhu Da-Wei Gong

OBJECTIVE To determine whether super-activation of PPARγ can reprogram human myoblasts into brown-like adipocytes and to establish a new cell model for browning research. METHODS To enhance the PPARγ signaling, M3, the transactivation domain of MyoD, was fused to PPARγ. PPARγ and M3-PPARγ-lentiviral vectors were used to convert human myoblasts into adipocytes. Brown adipocyte markers of the r...

2011
Laura L. Gathercole Stuart A. Morgan Iwona J. Bujalska David Hauton Paul M. Stewart Jeremy W. Tomlinson

Patients with glucocorticoid (GC) excess, Cushing's syndrome, develop a classic phenotype characterized by central obesity and insulin resistance. GCs are known to increase the release of fatty acids from adipose, by stimulating lipolysis, however, the impact of GCs on the processes that regulate lipid accumulation has not been explored. Intracellular levels of active GC are dependent upon the ...

2010
Adeline Divoux Joan Tordjman Danièle Lacasa Nicolas Veyrie Danielle Hugol Abdelhalim Aissat Arnaud Basdevant Michèle Guerre-Millo Christine Poitou Jean-Daniel Zucker Pierre Bedossa Karine Clément

OBJECTIVE Fibrosis is a newly appreciated hallmark of the pathological alteration of human white adipose tissue (WAT). We investigated the composition of subcutaneous (scWAT) and omental WAT (oWAT) fibrosis in obesity and its relationship with metabolic alterations and surgery-induced weight loss. RESEARCH DESIGN AND METHODS Surgical biopsies for scWAT and oWAT were obtained in 65 obese (BMI ...

2016
Rachel K Crowley Michael W O'Reilly Iwona J Bujalska Zaki K Hassan-Smith Jonathan M Hazlehurst Danielle R Foucault Paul M Stewart Jeremy W Tomlinson

AIMS The aim of this study was to assess depot-specific expression and secretion of secreted frizzled-related protein 2 (sFRP2) by adipose tissue and its effect on adipocyte biology. We measured serum sFRP2 concentrations in 106 patients in vivo to explore its relationship to fat mass, glycaemia and insulin resistance. METHODS Expression of sFRP2 in mouse and human tissues was assessed using ...

Journal: :Circulation 2007
Huaizhu Wu Sudip Ghosh Xiaoyuan Dai Perrard Lili Feng Gabriela E Garcia Jerry L Perrard John F Sweeney Leif E Peterson Lawrence Chan C Wayne Smith Christie M Ballantyne

BACKGROUND Obesity is associated with chronic inflammation, which includes increased macrophage accumulation in adipose tissue (AT) and upregulation of chemokines and cytokines. T cells also play important roles in chronic inflammatory diseases such as atherosclerosis but have not been well studied in obesity. METHODS AND RESULTS Flow cytometric analysis showed higher numbers of T cells and m...

2008
Pieter J. Oort Trina A. Knotts Michel Grino Nadia Naour Jean-Phillipe Bastard Karine Clément Natalia Ninkina Vladimir L. Buchman Paska A. Permana Xunyi Luo Guohua Pan Tamara N. Dunn Sean H. Adams

Recently, we characterized tumor suppressor candidate 5 (Tusc5) as an adipocyte-neuron PPARgamma target gene. Our objective herein was to identify additional genes that display distinctly high expression in fat and neurons, because such a pattern could signal previously uncharacterized functional pathways shared in these disparate tissues. gamma-Synuclein, a marker of peripheral and select cent...

Journal: :American journal of physiology. Endocrinology and metabolism 2009
Katja S C Gollisch Josef Brandauer Niels Jessen Taro Toyoda Ali Nayer Michael F Hirshman Laurie J Goodyear

Regular physical activity improves glucose tolerance and decreases adiposity. Our aim was to investigate the effects of exercise training on subcutaneous (inguinal) and visceral (parametrial) adipose tissue in rats that were fed a chow diet (13% fat) or made insulin resistant by a high-fat diet (60% fat). Sprague-Dawley rats performed 4 wk of voluntary wheel running or were kept as sedentary co...

2010
Francisco J. Ortega José M. Moreno-Navarrete Gerard Pardo Monica Sabater Manuela Hummel Anna Ferrer Jose I. Rodriguez-Hermosa Bartomeu Ruiz Wifredo Ricart Belen Peral José M. Fernández-Real

BACKGROUND Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, to date no study is available, to our knowledge, regarding miRNAs expression profile during human adipogenesis. Thereby, the aim of this study was to investigate whether miRNA pattern in human fa...

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