PURPOSE To investigate the hypothesis that a new matrix therapy agent (ReGeneraTing Agent, [RGTA]) would speed up the corneal reepithelialization, improve stromal healing, and reduce ocular symptoms after epi-off corneal cross-linking (CXL). METHODS Sixty eyes of 60 patients with progressive keratoconus were enrolled in the study. Epi-off accelerated CXL was performed in all patients. Sixty e...

Abstract Drought events have the potential to mediate tri-trophic interactions. Changes in plant quality influence herbivore performance, which affects prey availability and for natural enemies. Parasitoid wasps are particularly vulnerable these changes since their development is inextricably linked that of prey. However, we know little about indirect effects water limitation on parasitoid espe...

Inflammatory joint diseases are characterized by enhanced extracellular matrix degradation which is predominantly mediated by cytokine-stimulated upregulation of matrix metalloproteinase (MMP) expression. Besides tumour necrosis factor-alpha (TNF-alpha), Interleukin-1beta (IL-1beta) produced by articular chondrocytes and synovial macrophages, is the most important cytokine stimulating MMP expre...

Hansen N, Klein T, Magerl W, and Treed R-D. Psychophysical evidence for long-term potentiation of C-fiber and A -fiber pathways in humans by analysis of pain descriptors. J Neurophysiol 97: 2559 –2563, 2007. First published January 10, 2007; doi:10.1152/jn.01125.2006. Long-term potentiation of human pain perception (nociceptive LTP) to single electrical test stimuli was induced by high-frequenc...

BACKGROUND Cutaneous dysesthesia syndrome is a disorder characterized by chronic cutaneous symptoms without objective findings. Patients complain of burning, stinging, or itching, which is often triggered or exacerbated by psychological or physical stress. These symptoms may be manifestations of an underlying psychiatric disorder or may represent a type of chronic pain syndrome. OBSERVATIONS ...